Scientists develop a low-cost device to make cell therapy safer

Scientists develop a low-cost device to make cell therapy safer

A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.

In cell therapy, clinicians create what are known as induced pluripotent stem cells by reprogramming some skin or blood cells taken from a patient. To treat a spinal cord injury, they would coax these pluripotent stem cells to become progenitor cells, which are destined to differentiate into spinal cord cells. These progenitors are then transplanted back into the patient.

These new cells can regenerate part of the injured spinal cord. However, pluripotent stem cells that don’t fully change into progenitors can form tumors.

This research team developed a microfluidic cell sorter that can remove about half of the undifferentiated cells — those that can potentially become tumors — in a batch, without causing any damage to the fully-formed progenitor cells.

The high-throughput device, which doesn’t require special chemicals, can sort more than 3 million cells per minute. In addition, the researchers have shown that chaining many devices together can sort more than 500 million cells per minute, making this a more viable method to someday improve the safety of cell therapy treatments.

Plus, the plastic chip that contains the microfluidic cell sorter can be mass-produced in a factory at very low cost, so the device would be easier to implement at scale.

“Even if you have a life-saving cell therapy that is doing wonders for patients, if you cannot manufacture it cost-effectively, reliably, and safely, then its impact might be limited. Our team is passionate about that problem — we want to make these therapies more reliable and easily accessible,” says Jongyoon Han, an MIT professor of electrical engineering and computer science and of biological engineering, a member of the Research Laboratory of Electronics (RLE), and co-lead principal investigator of the CAMP (Critical Analytics for Manufacturing Personalized Medicine) research group at the Singapore-MIT Alliance for Research and Technology (SMART).

Han is joined on the paper by co-senior author Sing Yian Chew, professor of chemistry, chemical engineering, and biotechnology at the Lee Kong Chian School of Medicine and Materials Science and Engineering at Nanyang Technological University in Singapore and a CAMP principal investigator; co-lead authors Tan Dai Nguyen, a CAMP researcher; Wai Hon Chooi, a senior research fellow at the Singapore Agency for Science, Technology, and Research (A*STAR); and Hyungkook Jeon, an MIT postdoc; as well as others at NTU and A*STAR. The research appears today in Stem Cells Translational Medicine.

Reducing risk

The cancer risk posed by undifferentiated induced pluripotent stem cells remains one of the most pressing challenges in this type of cell therapy.

“Even if you have a very small population of cells that are not fully differentiated, they could still turn into cancer-like cells,” Han adds.

Clinicians and researchers often seek to identify and remove these cells by looking for certain markers on their surfaces, but so far researchers have not been able to find a marker that is specific to these undifferentiated cells. Other methods use chemicals to selectively destroy these cells, yet the chemical treatment techniques may be harmful to the differentiated cells.

The high-throughput microfluidic sorter, which can sort cells based on size, had been previously developed by the CAMP team after more than a decade of work. It has been previously used for sorting immune cells and mesenchymal stromal cells (another type of stem cell), and now the team is expanding its use to other stem cell types, such as induced pluripotent stem cells, Han says.

“We are interested in regenerative strategies to enhance tissue repair after spinal cord injuries, as these conditions lead to devasting functional impairment. Unfortunately, there is currently no effective regenerative treatment approach for spinal cord injuries,” Chew says. “Spinal cord progenitor cells derived from pluripotent stem cells hold great promise, since they can generate all cell types found within the spinal cord to restore tissue structure and function. To be able to effectively utilize these cells, the first step would be to ensure their safety, which is the aim of our work.”

The team discovered that pluripotent stem cells tend to be larger than the progenitors derived from them. It is hypothesized that before a pluripotent stem cell differentiates, its nucleus contains a large number of genes that haven’t been turned off, or suppressed. As it differentiates for a specific function, the cell suppresses many genes it will no longer need, significantly shrinking the nucleus.

The microfluidic device leverages this size difference to sort the cells.

Spiral sorting

Microfluidic channels in the quarter-sized plastic chip form an inlet, a spiral, and four outlets that output cells of different sizes. As the cells are forced through the spiral at very high speeds, various forces, including centrifugal forces, act on the cells. These forces counteract to focus the cells in a certain location in the fluid stream. This focusing point will be dependent on the size of the cells, effectively sorting them through separate outlets.

The researchers found they could improve the sorter’s operation by running it twice, first at a lower speed so larger cells stick to the walls and smaller cells are sorted out, then at a higher speed to sort out larger cells.

In a sense, the device operates like a centrifuge, but the microfluidic sorter does not require human intervention to pick out sorted cells, Han adds.

The researchers showed that their device could remove about 50 percent of the larger cells with one pass. They conducted experiments to confirm that the larger cells they removed were, in fact, associated with higher tumor risk.

“While we can’t remove 100 percent of these cells, we still believe this is going to reduce the risk significantly. Hopefully, the original cell type is good enough that we don’t have too many undifferentiated cells. Then this process could make these cells even safer,” he says.

Importantly, the low-cost microfluidic sorter, which can be produced at scale with standard manufacturing techniques, does not use any type of filtration. Filters can become clogged or break down, so a filter-free device can be used for a much longer time.

Now that they have shown success at a small scale, the researchers are embarking on larger studies and animal models to see if the purified cells function better in vivo.

Nondifferentiated cells can become tumors, but they can have other random effects in the body, so removing more of these cells could boost the efficacy of cell therapies, as well as improve safety.

“If we can convincingly demonstrate these benefits in vivo, the future might hold even more exciting applications for this technique,” Han says.

This research is supported, in part, by the National Research Foundation of Singapore and the Singapore-MIT Alliance for Research and Technology.

Technique could improve the sensitivity of quantum sensing devices

Technique could improve the sensitivity of quantum sensing devices

In quantum sensing, atomic-scale quantum systems are used to measure electromagnetic fields, as well as properties like rotation, acceleration, and distance, far more precisely than classical sensors can. The technology could enable devices that image the brain with unprecedented detail, for example, or air traffic control systems with precise positioning accuracy.

As many real-world quantum sensing devices are emerging, one promising direction is the use of microscopic defects inside diamonds to create “qubits” that can be used for quantum sensing. Qubits are the building blocks of quantum devices.

Researchers at MIT and elsewhere have developed a technique that enables them to identify and control a greater number of these microscopic defects. This could help them build a larger system of qubits that can perform quantum sensing with greater sensitivity.

Their method builds off a central defect inside a diamond, known as a nitrogen-vacancy (NV) center, which scientists can detect and excite using laser light and then control with microwave pulses. This new approach uses a specific protocol of microwave pulses to identify and extend that control to additional defects that can’t be seen with a laser, which are called dark spins.

The researchers seek to control larger numbers of dark spins by locating them through a network of connected spins. Starting from this central NV spin, the researchers build this chain by coupling the NV spin to a nearby dark spin, and then use this dark spin as a probe to find and control a more distant spin which can’t be sensed by the NV directly. The process can be repeated on these more distant spins to control longer chains.

“One lesson I learned from this work is that searching in the dark may be quite discouraging when you don’t see results, but we were able to take this risk. It is possible, with some courage, to search in places that people haven’t looked before and find potentially more advantageous qubits,” says Alex Ungar, a PhD student in electrical engineering and computer science and a member of the Quantum Engineering Group at MIT, who is lead author of a paper on this technique, which is published today in PRX Quantum.

His co-authors include his advisor and corresponding author, Paola Cappellaro, the Ford Professor of Engineering in the Department of Nuclear Science and Engineering and professor of physics; as well as Alexandre Cooper, a senior research scientist at the University of Waterloo’s Institute for Quantum Computing; and Won Kyu Calvin Sun, a former researcher in Cappellaro’s group who is now a postdoc at the University of Illinois at Urbana-Champaign.

Diamond defects

To create NV centers, scientists implant nitrogen into a sample of diamond.

But introducing nitrogen into the diamond creates other types of atomic defects in the surrounding environment. Some of these defects, including the NV center, can host what are known as electronic spins, which originate from the valence electrons around the site of the defect. Valence electrons are those in the outermost shell of an atom. A defect’s interaction with an external magnetic field can be used to form a qubit.

Researchers can harness these electronic spins from neighboring defects to create more qubits around a single NV center. This larger collection of qubits is known as a quantum register. Having a larger quantum register boosts the performance of a quantum sensor.

Some of these electronic spin defects are connected to the NV center through magnetic interaction. In past work, researchers used this interaction to identify and control nearby spins. However, this approach is limited because the NV center is only stable for a short amount of time, a principle called coherence. It can only be used to control the few spins that can be reached within this coherence limit.

In this new paper, the researchers use an electronic spin defect that is near the NV center as a probe to find and control an additional spin, creating a chain of three qubits.

They use a technique known as spin echo double resonance (SEDOR), which involves a series of microwave pulses that decouple an NV center from all electronic spins that are interacting with it. Then, they selectively apply another microwave pulse to pair the NV center with one nearby spin.

Unlike the NV, these neighboring dark spins can’t be excited, or polarized, with laser light. This polarization is a required step to control them with microwaves.

Once the researchers find and characterize a first-layer spin, they can transfer the NV’s polarization to this first-layer spin through the magnetic interaction by applying microwaves to both spins simultaneously. Then once the first-layer spin is polarized, they repeat the SEDOR process on the first-layer spin, using it as a probe to identify a second-layer spin that is interacting with it.

Controlling a chain of dark spins

This repeated SEDOR process allows the researchers to detect and characterize a new, distinct defect located outside the coherence limit of the NV center. To control this more distant spin, they carefully apply a specific series of microwave pulses that enable them to transfer the polarization from the NV center along the chain to this second-layer spin.

“This is setting the stage for building larger quantum registers to higher-layer spins or longer spin chains, and also showing that we can find these new defects that weren’t discovered before by scaling up this technique,” Ungar says.

To control a spin, the microwave pulses must be very close to the resonance frequency of that spin. Tiny drifts in the experimental setup, due to temperature or vibrations, can throw off the microwave pulses.

The researchers were able to optimize their protocol for sending precise microwave pulses, which enabled them to effectively identify and control second-layer spins, Ungar says.

“We are searching for something in the unknown, but at the same time, the environment might not be stable, so you don’t know if what you are finding is just noise. Once you start seeing promising things, you can put all your best effort in that one direction. But before you arrive there, it is a leap of faith,” Cappellaro says.

While they were able to effectively demonstrate a three-spin chain, the researchers estimate they could scale their method to a fifth layer using their current protocol, which could provide access to hundreds of potential qubits. With further optimization, they may be able to scale up to more than 10 layers.

In the future, they plan to continue enhancing their technique to efficiently characterize and probe other electronic spins in the environment and explore different types of defects that could be used to form qubits.

This research is supported, in part, by the U.S. National Science Foundation and the Canada First Research Excellence Fund.

3 Questions: The Climate Project at MIT

MIT is preparing a major campus-wide effort to develop technological, behavioral, and policy solutions to some of the toughest problems now impeding an effective global climate response. The Climate Project at MIT, as the new enterprise is known, includes new arrangements for promoting cross-Institute collaborations and new mechanisms for engaging with outside partners to speed the development and implementation of climate solutions.

MIT News spoke with Richard K. Lester, MIT’s vice provost for international activities, who has helped oversee the development of the project.

Q: What is the Climate Project at MIT?

A: In her inaugural address last May, President Kornbluth called on the MIT community to join her in a “bold, tenacious response” to climate change. The Climate Project at MIT is a response to that call. It aims to mobilize every part of MIT to develop, deliver, and scale up practical climate solutions, as quickly as possible.

3 Questions: The Climate Project at MIT

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At MIT, well over 300 of our faculty are already working with their students and research staff members on different aspects of the climate problem. Almost all of our academic departments and more than a score of our interdepartmental labs and centers are involved in some way. What they are doing is remarkable, and this decentralized structure reflects the best traditions of MIT as a “bottom up,” entrepreneurial institution. But, as President Kornbluth said, we must do much more. We must be bolder in our research choices and more creative in how we organize ourselves to work with each other and with our partners. The purpose of the Climate Project is to support our community’s efforts to do bigger things faster in the climate domain. We will have succeeded if our work changes the trajectory of global climate outcomes for the better.

I want to be clear that the clay is still wet here. The Climate Project will continue to take shape as more members of the MIT community bring their excellence, their energy, and their ambition to bear on the climate challenge. But I believe we have a vision and a framework for accelerating and amplifying MIT’s real-world climate impact, and I know that President Kornbluth is eager to share this progress report with the MIT community now to convey the breadth and ambition of what we’re planning.

Q: How will the project be organized?

A: The Climate Project will have three core components: the Climate Missions; their offshoots, the Climate Frontier Projects; and Climate HQ. A new vice president for climate will lead the enterprise.

Initially there will be six missions, which you can read about in the plan. Each will address a different domain of climate impact where new solutions are required and where a critical mass of research excellence exists at MIT. One such mission, of course, is to decarbonize energy and industry, an area where we estimate that about 150 of our faculty are already working.

The mission leaders will build multidisciplinary problem-solving communities reaching across the Institute and beyond. Each of these will be charged with roadmapping and assessing progress toward its mission, identifying critical gaps and bottlenecks, and launching applied research projects to accelerate progress where the MIT community and our partners are well-positioned to achieve impactful results. These projects — the climate frontier projects — will benefit from active, professional project management, with clear metrics and milestones. We are in a critical decade for responding to climate change, so it’s important that these research projects move quickly, with an eye on producing real-world results.

The new Climate HQ will drive the overall vision for the Climate Project and support the work of the missions. We’ve talked about a core focus on impact-driven research, but much is still unknown about the Earth’s physical and biogeochemical systems, and there is also much to be learned about the behavior of the social and political systems that led us to the very difficult situation the world now faces. Climate HQ will support fundamental research in the scientific and humanistic disciplines related to climate, and will promote engagement between these disciplines and the missions. We must also advance climate-related education, led by departments and programs, as well as policy work, public outreach, and more, including an MIT-wide student-centric Climate Corps to elevate climate-related, community-focused service in MIT’s culture.

Q: Why are partners a key part of this project?

A: It is important to build strong partners right from the very start for our innovations, inventions, and discoveries to have any prospect of achieving scale. And in many cases, with climate change, it’s all about scale.

One of the aims of this initiative is to strengthen MIT’s climate “scaffolding” — the people and processes connecting what we do on campus to the practical world of climate impact and response. We can build on MIT’s highly developed infrastructure for translation, innovation, and entrepreneurship, even as we promote other important pathways to scale involving communities, municipalities, and other not-for-profit organizations. Working with all these different organizations will help us build a broad infrastructure to help us get traction in the world. On a related note, the Sloan School of Management will be sharing details in the coming days of an exciting new effort to enhance MIT’s contributions in the climate policy arena.

MIT is committing $75 million, including $25 million from Sloan, at the outset of the project. But we anticipate developing new partnerships, including philanthropic partnerships, to increase that scope dramatically.

Letter to the MIT community: Announcing the Climate Project at MIT

Letter to the MIT community: Announcing the Climate Project at MIT

The following letter was sent to the MIT community today by President Sally Kornbluth.

Dear members of the MIT community,

At my inauguration, echoing a sentiment I heard everywhere on my campus listening tour, I called on the people of MIT to come together in new ways to marshal a bold, tenacious response to the run-away crisis of climate change.

I write with an update on how we’re bringing this vision to life.

This letter includes several significant announcements – including an accelerated search for faculty leaders and a very substantial commitment of MIT funds – so please read on.

A Record of MIT Leadership

Since the late Professor Jule Charney led a 1979 National Academy of Sciences report that foretold the likely risks of global warming, MIT researchers have made pioneering contributions in countless relevant fields. Today, more than 300 faculty, working with their students and research and teaching staff, are engaged in leading-edge work on climate issues. The Institute has also taken important steps to enhance climate education, expand public outreach on climate and decarbonize the campus.

But – as the community told me loud and clear – this moment demands a different order of speed, ambition, focus and scale.

The Climate Project at MIT

After extensive consultation with more than 150 faculty and senior researchers across the Institute – and building on the strengths of Fast Forward: MIT’s Climate Action Plan for the Decade, issued in 2021 – Vice Provost Richard Lester has led us in framing a new approach: the Climate Project at MIT.  

Representing a compelling new strategy for accelerated, university-led innovation, the Climate Project at MIT will focus our community’s talent and resources on solving critical climate problems with all possible speed – and will connect us with a range of partners to deliver those technological, behavioral and policy solutions to the world.

As Richard explains in this MIT News 3Q, the Climate Project at MIT is still in its early stages; as it gains new leaders and new allies from academia, industry, philanthropy and government, it will continue to be shaped by their insight and expertise.

For now, we begin with a new structure and strategy for organizing the work. The Climate Project at MIT will consist of three interlocking elements:

  • The Climate Missions
  • The Climate Frontier projects
  • The Climate HQ

To learn more about these components, I encourage you to read this summary of the plan (PDF). 

Recruiting Leaders for the Six Climate Missions

The central focus will be six Climate Missions – each constituting a cross-disciplinary Institute-wide problem-solving community focused on a strategic area of the climate challenge:

  • Decarbonizing Energy and Industry
  • Restoring the Atmosphere, Protecting the Land and Oceans
  • Empowering Frontline Communities
  • Building and Adapting Healthy, Resilient Cities
  • Inventing New Policy Approaches
  • Wild Cards

We’re now recruiting an MIT faculty leader for each of these missions – on an accelerated timeline. We welcome any interested faculty member to apply to be a Climate Mission leader or to nominate a colleague. Please submit your CV and statement of interest at climatesearch@mit.edu by February 22.

You can learn more about the role on the Climate Project’s preliminary webpage. All submissions will be treated as confidential.

A New Leadership Role, a Search Committee – and Significant MIT Resources

The Climate Project at MIT is gathering steam – and we will build its momentum with these three important steps.

1. Vice President for Climate

To match the prime importance of this work, we have created a new leadership role, reporting to me: Vice President for Climate (VPC). The VPC will oversee the Climate Project at MIT, take the lead on fundraising and implementation, and shape its strategic vision. We are opening the search now and welcome candidates from inside and outside MIT. You may submit your CV and statement of interest in the VPC role at climatesearch@mit.edu. A formal job description will be posted soon.

2. Climate Search Advisory Committee

To advise me in selecting the six mission leaders and the VPC, I have appointed the following faculty members to serve on the Climate Search Advisory Committee:

  • Richard Lester, Chair
  • Daron Acemoglu
  • Yet-Ming Chiang
  • Penny Chisholm
  • Dava Newman
  • Ron Rivest
  • Susan Solomon
  • John Sterman
  • Larry Vale
  • Rob van der Hilst
  • Anne White

3. $75 million in support from the Institute and MIT Sloan

And finally: We will jumpstart the Climate Project at MIT with a commitment of $50 million in Institute resources – the largest direct investment the Institute has ever made in funding climate work, and just the beginning of a far more ambitious effort to raise the funds this extraordinary challenge demands. In addition, the Sloan School will contribute $25 million to endow a new climate policy center, to be formally announced in the coming days. Together, these funds will allow for early advances and express the seriousness of our intentions to potential partners around the world.

*    *    *

The Climate Project at MIT is ambitious, multifaceted and more complex than I could capture in a letter; I urge you to explore the summary of the plan (PDF) to see where you might fit. There will be a place for everyone, including all of our existing climate-involved DLCs. (And you might enjoy this brief video, which celebrates MIT’s distinctive gift for collaborative problem-solving on a grand scale.)

At last spring’s inauguration, I said I hoped that, a decade hence, all of us at MIT could take pride in having “helped lead a powerful cross-sector coalition and placed big bets on big solutions, to dramatically accelerate progress against climate change.”

With your creativity, support and drive, we have every reason to hope that the Climate Project at MIT can make that aspiration real.

With enthusiasm and anticipation,

Sally Kornbluth

MIT physicists capture the first sounds of heat “sloshing” in a superfluid

In most materials, heat prefers to scatter. If left alone, a hotspot will gradually fade as it warms its surroundings. But in rare states of matter, heat can behave as a wave, moving back and forth somewhat like a sound wave that bounces from one end of a room to the other. In fact, this wave-like heat is what physicists call “second sound.”

Signs of second sound have been observed in only a handful of materials. Now MIT physicists have captured direct images of second sound for the first time.

The new images reveal how heat can move like a wave, and “slosh” back and forth, even as a material’s physical matter may move in an entirely different way. The images capture the pure movement of heat, independent of a material’s particles.

“It’s as if you had a tank of water and made one half nearly boiling,” Assistant Professor Richard Fletcher offers as analogy. “If you then watched, the water itself might look totally calm, but suddenly the other side is hot, and then the other side is hot, and the heat goes back and forth, while the water looks totally still.”

Led by Martin Zwierlein, the Thomas A Frank Professor of Physics, the team visualized second sound in a superfluid — a special state of matter that is created when a cloud of atoms is cooled to extremely low temperatures, at which point the atoms begin to flow like a completely friction-free fluid. In this superfluid state, theorists have predicted that heat should also flow like a wave, though scientists had not been able to directly observe the phenomenon until now.

MIT physicists capture the first sounds of heat “sloshing” in a superfluid

Titled “2nd Sound,” It has red and blue sections but only the blue section is sloshing around.
First sound, depicted in a simple animation, is ordinary sound in the form of density waves, in which normal fluid and superfluid oscillate together. 

Second sound is the movement of heat, in which superfluid and normal fluid “slosh” against each other, while leaving the density constant.

Images: Courtesy of the researchers

The new results, reported today in the journal Science, will help physicists get a more complete picture of how heat moves through superfluids and other related materials, including superconductors and neutron stars.

“There are strong connections between our puff of gas, which is a million times thinner than air, and the behavior of electrons in high-temperature superconductors, and even neutrons in ultradense neutron stars,” Zwierlein says. “Now we can probe pristinely the temperature response of our system, which teaches us about things that are very difficult to understand or even reach.”

Zwierlein and Fletcher’s co-authors on the study are first author and former physics graduate student Zhenjie Yan and former physics graduate students Parth Patel and Biswaroop Mukherjee, along with Chris Vale at Swinburne University of Technology in Melbourne, Australia. The MIT researchers are part of the MIT-Harvard Center for Ultracold Atoms (CUA).

Super sound

When clouds of atoms are brought down to temperatures close to absolute zero, they can transition into rare states of matter. Zwierlein’s group at MIT is exploring the exotic phenomena that emerge among ultracold atoms, and specifically fermions — particles, such as electrons, that normally avoid each other.

Under certain conditions, however, fermions can be made to strongly interact and pair up. In this coupled state, fermions can flow in unconventional ways. For their latest experiments, the team employs fermionic lithium-6 atoms, which are trapped and cooled to nanokelvin temperatures.

In 1938, the physicist László Tisza proposed a two-fluid model for superfluidity — that a superfluid is actually a mixture of some normal, viscous fluid and a friction-free superfluid. This mixture of two fluids should allow for two types of sound, ordinary density waves and peculiar temperature waves, which physicist Lev Landau later named “second sound.”  

Since a fluid transitions into a superfluid at a certain critical, ultracold temperature, the MIT team reasoned that the two types of fluid should also transport heat differently: In normal fluids, heat should dissipate as usual, whereas in a superfluid, it could move as a wave, similarly to sound.

“Second sound is the hallmark of superfluidity, but in ultracold gases so far you could only see it in this faint reflection of the density ripples that go along with it,” Zwierlein says. “The character of the heat wave could not be proven before.”

Tuning in

Zwierlein and his team sought to isolate and observe second sound, the wave-like movement of heat, independent of the physical motion of fermions in their superfluid. They did so by developing a new method of thermography — a heat-mapping technique. In  conventional materials one would use infrared sensors to image heat sources.

But at ultracold temperatures, gases do not give off infrared radiation. Instead, the team developed a method to use radio frequency to “see” how heat moves through the superfluid. They found that the lithium-6 fermions resonate at different radio frequencies depending on their temperature: When the cloud is at warmer temperatures, and carries more normal liquid, it resonates at a higher frequency. Regions in the cloud that are colder resonate at a lower frequency.

The researchers applied the higher resonant radio frequency, which prompted any normal, “hot” fermions in the liquid to ring in response. The researchers then were able to zero in on the resonating fermions and track them over time to create “movies” that revealed heat’s pure motion — a sloshing back and forth, similar to waves of sound.

“For the first time, we can take pictures of this substance as we cool it through the critical temperature of superfluidity, and directly see how it transitions from being a normal fluid, where heat equilibrates boringly, to a superfluid where heat sloshes back and forth,” Zwierlein says.

The experiments mark the first time that scientists have been able to directly image second sound, and the pure motion of heat in a superfluid quantum gas. The researchers plan to extend their work to more precisely map heat’s behavior in other ultracold gases. Then, they say their findings can be scaled up to predict how heat flows in other strongly interacting materials, such as in high-temperature superconductors, and in neutron stars.

“Now we will be able to measure precisely the thermal conductivity in these systems, and hope to understand and design better systems,” Zwierlein concludes.

This work was supported by the National Science Foundation (NSF), the Air Force Office of Scientific Research, and the Vannevar Bush Faculty Fellowship. The MIT team is part of the MIT-Harvard Center for Ultracold Atoms (an NSF Physics Frontier Center) and affiliated with the MIT Department of Physics and the Research Laboratory of Electronics (RLE).