A chronicler of the biotech boom

A chronicler of the biotech boom

For decades now, MIT’s Kendall Square neighborhood has been dotted by cranes, scaffolding, and construction sites — the unofficial symbols of the biotechnology boom that has made East Cambridge an industry capital.

True, there are other kinds of tech firms in Kendall Square, from Silicon Valley giants to startups. But the Kendall area is one of the places where the biotech business launched in the 1970s. It’s where blockbuster drugs have been developed and an innovative Covid-19 vaccine was created on short notice, and it keeps powering onward today.

“It’s the most vibrant biotechnology cluster in the world,” says MIT Associate Professor Robin Scheffler, a historian of science. “We are talking about a location that plays a huge role in defining the future of how biology can improve the human experience.”

Scheffler has become a historian of this transformation. An expert in the history of bioscience, he is currently writing a book about the rise and further rise of biotech in Kendall Square and greater Boston. Based heavily on original archival documents, Scheffler’s work will present a new look at everyday life in labs to further understand these companies, how innovation clusters function, and how medical innovations shape health care policy.

“A defining characteristic of Kendall Square’s ascendancy in biotechnology is its sheer density,” Scheffler says. “It’s so closely packed together and includes all these other dimensions of science and biology — hospitals, medical schools, and universities. Research and commercialization and production happen in this very small area.”

He adds: “Looking at the Boston area gives you a window into the evolution and growth of the industry as a whole.”

Studying the fairly recent past lets Scheffler illuminate how the scientific enterprise works today. Scheffler’s first book, “A Contagious Cause,” published in 2019, examined postwar fears that there was a general, transmittable “cancer virus.” A big federal funding effort in the 1960s helped prove otherwise, and in the process uncovered oncogenes — a driver of many cancers — while helping develop molecular biology. Meanwhile, researchers have since found other ways that viral illnesses are implicated in certain kinds of cancers.

In short, biotechnology moves rapidly and unpredictably, and there is never a bad time to analyze its progress. For his research and teaching, Scheffler earned tenure at MIT last year.

Building bridges

Asked about his own career trajectory, Scheffler — like many a good historian — can cite multiple factors to explain it, with some representing root causes. Scheffler has a long-standing inclination to find different fields of study fascinating, and to link them together. The history of science allows him to do that perpetually.

Growing up in California, Scheffler enjoyed philosophy, science, and math as a student, then attended the University of Chicago as an undergraduate and started redefining his interests a little.

“By the time I got to college I really enjoyed bridging things together,” he says. “I ended up being interested in two things, history and chemistry, that are both bridge-building fields. History bridges humanistic questions about life and experience with the social sciences, and chemistry bridges physics with biology.”

Scheffler received his undergraduate degree in both history and chemistry, and credits a few Chicago faculty from the time — Ronald Suny, Cathy Gere, and the late Alison Winter — with spurring his interest in the history of science. He earned a master’s degree in the history and philosophy of science from Cambridge University, supported by a National Science Foundation Graduate Fellowship — unusually for a historian of science — then moved to Yale University for his doctoral studies.

There, with historian of science Daniel Kevles as his advisor, Scheffler zeroed in on tumor viruses as his dissertation topic on its interdisciplinary merits.

“If I followed tumor viruses, I would have a historical object that allowed me to go to many realms: politics and policy, medicine, molecular biology,” Scheffler says. “I wanted to produce history that dissolved disciplinary divides. I think it’s important because it allows scientists to understand they are members of society and not just of the scientific community, but it also produces, I hope, a nuanced appreciation of what science can do.”

Scheffler also hit on a timely topic by publishing a major book on federally backed virus research just before the global Covid-19 pandemic occurred.

“Interest in viruses has spiked,” Scheffler says. “People want to know about the history of viral research in the 20th century, and regard it as a resource.” After the pandemic started, when Scheffler taught a course about biotech, he says, in class discussions, “Everybody’s example of biotechnology was a vaccine.”

Of his first book, he also notes: “Viruses were objects of an ambitious and positive effort to structure research. The overall vision that the government could step in to make [and support] a valuable contribution remains a very powerful idea. Having an appreciation for what was happening then, I hope, provides useful ideas for how to approach the present.”

A spotlight on “invisible technicians”

While wrapping up the book, Scheffler started writing a chapter about how the hunt for tumor viruses had helped create the contemporary biotech industry. But it did not quite fit with the rest of his material.

“I realized I wasn’t looking at the final chapter of a first book, I was looking at the outline of a second book,” Scheffler says.

After that dawned on him, Scheffler began researching the second project, centering it on the Boston area. And while some parts of the Kendall Square biotech boom have been well-documented, others remain less chronicled — such as the daily process of lab work that turns concepts into life-saving medicines.

“I’m very interested in what historians of science call ‘invisible technicians,’” Scheffler says. “We know a fair amount about biotech’s founders. I’m focused on people who are taking scientific ideas and transforming them into meaningful products. Otherwise, they’re just good ideas. Focusing on that level also knits the industry into the city of Cambridge, because that’s where the social dimension of this industry really takes place. It all stacks up in understanding how the world’s leading biotechnology cluster operates.”

Scheffler is looking in detail at the ways academia provides an essential talent pool for the biotech industry and serves as an anchor point for the Boston-area cluster of companies. He is also examining a full range of economic forces, urban planning issues, and other matters essential to thinking about the operations of any industrial cluster of companies. It does not hurt, he notes, to be living in the place he is studying.

“It’s been wonderful to get to know where I live, and understand the layers of history beneath my office in East Cambridge,” Scheffler says. “The opportunity to research this project while living in its midst is a special experience. People have provided me with great suggestions and observations.”

Meanwhile, the cranes and booms keep arriving in East Cambridge, the frames of buildings keep rising, and new firms keep exploring leading-edge concepts in medical research.

“At every single juncture, more companies arrive and it continues to grow,” Scheffler says.

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Penny’s Big Breakaway Preview – Bauhausian Rhapsody – Game Informer

Introduction

Sonic Mania is widely regarded as one of the blue blur’s best games. More than six years after its 2017 release, that sentiment remains as strong as ever, even after recent outings like 2022’s Sonic Frontiers and this year’s Sonic Superstars. While published by Sega, longtime Sonic fans who grew up playing the series, like Christian Whitehead, Hunter Bridges, Dave Padilla, Brad Flick, Tom Fry, and others, led the game’s development. And without speculating too much, the degree of separation afforded to these fans-turned-developers allowed Sonic Mania to feel like both a fresh breath of air and a return to form.

Not wanting to wade too deep into the world of independent contracts and wishing to maintain the friendship between each other strengthened in Sonic Mania’s development, the five of them formed Evening Star months after the game’s release. Studio CEO and executive producer Padilla, CTO and game director Bridges, creative director and lead engine architect Whitehead, design director Flick, and art director Fry all admit the easy follow-up was right there: A Sonic Mania-type 2D platformer. It’s what fans of Sonic Mania wanted, and to their credit, they worked with Sega on potential sequel ideas before amicably parting ways. But, unsatisfied with the easy answer, Evening Star got to work on a 3D momentum-based platformer inspired by Tony Hawk’s Pro Skater, an early 20th Century ballet, and 1995’s Jumping Flash on PlayStation.

Penny’s Big Breakaway Preview – Bauhausian Rhapsody – Game Informer

Evening Star

“We always had this idea of, ‘Wouldn’t it be great if we had a character that could use a yo-yo to do different moves?’” Whitehead says. “Initially, we jotted them down on a 2D playfield, but there were several concurrent themes swirling in the background. At least for me, my perspective as a developer is I’ve spent the last decade working exclusively on 2D pixel art, so I really wanted to expand and prove that I could do something more than just one particular genre.”

Whitehead says he’s aware Penny’s Big Breakaway is another platformer but says it’s a different flavor in a different dimension. After playing more than two hours of the game myself, experiencing the first three of 11 regions in the world of Macaroon, including three different boss stages and special Star Globe bonus levels, that much is clear. Knowing the development leads of Sonic Mania are responsible for what I play, it’s impossible to deny the momentum-based inspiration that lives in both titles. But Whitehead’s right – even beyond the obvious shift from 2D to 3D, Penny’s Big Breakaway features a different flavor. It is not just a new flavor for these developers but something unique in the long-standing platforming genre.

Breaking the Standards

Breaking The Standards

I’m terrible at the game, at least for the first handful of stages. It doesn’t help that I just watched Bridges speed through them like someone with intimate knowledge of every stage’s challenges, but I’m slow and struggle to combo yo-tagonist Penny’s yo-yo-based moves across ramps, flag poles, gaps, and more. Penny can toss her yo-yo forward to attack enemies and break barrels with a button on a controller or, more curiously, by flicking the right stick in a direction. And that directional input is independent of Penny, meaning you can flick the yo-yo to her right while she walks left. It’s admittedly bizarre at first – not because it doesn’t feel good, but because it’s so different from how I typically interact with the combat and moveset of a 3D platformer mascot.

In the same vein, Penny can double jump, but instead of gaining a good amount of height with a second jump, she gains a barely noticeable amount; the purpose of her double jump isn’t height but a stop in momentum, Bridges tells me. She can dash by tossing her yo-yo forward, performed by flicking the right stick in the same direction twice, and she can swing left and right, forward and backward, on her yo-yo anywhere in the air as well.

Although it takes me some time – something I welcome because it’s rare to experience a new moveset that challenges my preconceptions of a genre – I finish my Penny’s Big Breakaway play time with the realization that it’s not a 3D platformer in the vein of something Nintendo might create, another challenged preconception. On the one hand, it’s a Tony Hawk’s Pro Skater-inspired platformer with an emphasis on momentum that will appeal heavily to speedrunners and time trial fans, with a constant score and Devil May Cry-style combo tracker on the right side of the screen, too. On the other, it’s a team’s love letter to the weird and sometimes broken platformers of the 3D genre’s early days. Together as a complete package, it rules.

“The rules [of 3D platformers] at that stage weren’t really established that well,” Whitehead says. “I remember growing up playing a lot of PlayStation games where they were maybe a bit rough around the edges but trying to grapple platforming mechanics in 3D, and I felt really inspired by that era. I experienced that as a kid, but I wanted to experience that as a developer.”

A Roundtable Philosophy

A Roundtable Philosophy

Whitehead, admitting creative selfishness, says he wanted to try and make a PlayStation-style 3D platformer that fixes the problems he experienced growing up with the genre. The small slice I’ve played proves Evening Star is on the right path. But in speaking to others within Evening Star, like Bridges, Fry, Flick, and Padilla, it’s clear everyone is all-in on that idea. Even Fry, the art director on paper, says he was involved in all kinds of decisions outside of his development realm, a philosophy everyone else expresses too. “The collaborative effort is an intrinsic part of the team,” Fry says. “Not one person has an idea and everyone follows them like the Pied Piper with it. It’s something where we believe everyone has something of value to throw into the pot, and with the art, that’s certainly no different. I refer to it as a roundtable philosophy.”

That collaborative energy even made its way into the so-far-amazing score of Penny’s Big Breakaway, which utilizes a wide range of weird synthesizer instruments, instrumentation from genres like Latin and Calypso, and more to create a jazz-like symphony of music. Bridges, Whitehead, and others in the team contributed to the score in various ways, even after Evening Star hired Streets of Rage 4 and TMNT: Shredder’s Revenge composer Tee Lopes, who the team also worked with on Sonic Mania, and Sean Bialo to create the score.

Performance Art

Performance Art

If one aspect of Penny’s Big Breakaway speaks most to its early PlayStation inspiration, it’s the art direction. Inspired by the early 20th Century Triadisches Ballett and the Germanic Bauhaus art movement from the same period, combining colorful abstract ideas with primitive geometry, the world of Macaroon feels like one big performance. Your social status is defined by the performance you can give to denizens of the world. Every stage ends with a “Busker” bonus that requires quick and accurate QTE sequence completion to add additional points to your total score. Within each stage are three denizen challenges, like collecting four missing tax forms for an electric company while riding Penny’s yo-yo like a unicycle, and during the Busker bonus, the denizens you help watch you perform.

Even the conceit of the narrative speaks to the idea of performance art being everything – Penny attends a talent show after finding a special yo-yo with an insatiable hunger and, instead of wowing the emperor with a showstopping performance, the yo-yo eats the emperor’s clothes. She spends the rest of the game running further and further away from the emperor and Macaroon’s capital, chased to the world’s edges by the emperor’s ever-present penguins, only temporarily slowed by your efforts and never outright defeated.

“We want the game to keep the flow and dribble going,” Bridges tells me. “We really wanted to have that rhythm […] and never interrupt that. It’s a game where the most skilled players can theoretically make it through a level in an unbroken string of moves. That’s Penny’s masterful performance.”

That’s why Evening Star controls the camera at all times, which requires a flip in my brain. With three denizen challenges to complete and three Show Pieces to find in each level, I want to explore every nook and cranny. But without camera control, I can’t, and I hate this at first. It’s only after realizing that if Evening Star isn’t allowing the camera to take me here or there, then there isn’t anything to miss that I begin to play on the team’s terms. This switch is freeing, realizing Penny’s platforming playground is predicated on my ability to keep moving forward to where Evening Star was taking me in its design. With thoughtful movement and a keen eye, completing every challenge and finding every Show Piece feels intrinsic to Penny’s “performance” in each stage.

The game clashed with every notion I had of 3D platforming. I wanted to take things slow; I wanted to search every corner for something; I wanted to take my time. But Penny’s Big Breakaway is a welcome antithesis to everything (mostly) Nintendo had taught me about this genre. It’s a bold design choice and one I would have called risky on paper. In talking with Evening Star, it’s clear it understood that risk going into its first original game and IP. However, each member I spoke to expressed humble confidence in their respective facets of the game’s development.

“There are a lot of skills we really excel at when making games, and a lot of specific nuances we bring to the table because of our team dynamic and our tools, and I don’t think it’s going to be a complete surprise,” Padilla says. “I think a lot of folks are going to see this as something completely new and something completely original, but in terms of what we’ve done before and what we’re doing now, and hopefully what we’re doing in the future, folks are going to be able to connect the dots.” 


This article originally appeared in Issue 362 of Game Informer.

National Change Your Password Day – 2024 – Best Practices

National Change Your Password Day – 2024 – Best Practices

EXECUTIVE SUMMARY:

National Change Your Password Day is celebrated on the first of February each year, as a day of awareness.

As you already know, credential exploitation is unbelievably profitable for cyber criminals. More than 775 million credentials are currently available for sale on the dark web. Bank account details sell for more than $4,000 each.

Regular password rotation, combined with adherence to password creation best practices, prevents hackers from guessing passwords, using tools to crack passwords, and from effectively weaponizing credentials purchased through underground marketplaces.

National Change Your Password Day might not have the allure of other holidays (the naming consultants were apparently on vacation when it was created), but the day serves as a reminder for organizations to enhance password security measures.

Unauthorized organizational data access could result in lost revenue, lost market share and lost company credibility. But stop losing sleep over it. Upgrade your password security strategy with the following tips:

7 easy password security upgrades that you can implement today

1. Identity and access management (IAM). Automated identity and access management solutions boost security and provide administrators with greater control over users’ access to systems.

In turn, IAM empowers organizations to prevent identity theft, to limit data loss, and to stop unauthorized access to sensitive business data.

2. Educate employees about best practices. Remind in-office employees to avoid writing passwords down on sticky notes. Tell employees not to save passwords to browsers, as a wide range of malware and extensions can extract sensitive data from them.

Inform employees about the risks of using the same password over and over again, with different numbers at the end. Explain that hackers know that people commonly end passwords with exclamation points. Reinforce information about the risks associated with sharing login credentials.

These are just a handful of specific, yet extremely important, things about which to educate employees.

3. Limit the number of allowed password attempts. While it’s true that employees occasionally forget their passwords, cyber criminals are liable to exploit access attempt opportunities for their own gain.

In a classic example, a cyber criminal may obtain an employee’s email address, and then request a password reset. Depending on the reset set-up, the cyber criminal may attempt to match the recovered password to a variety of different accounts and systems, in an effort to break in.

Placing a limit on the number of allowed password attempts increases password security, as it reduces the chance that someone will successfully manipulate systems by matching a password and usernames.

4. Audit systems for extraneous employee accounts. Occasionally, employees create backdoor access to computer systems, for legitimate purposes, by creating multiple user accounts.

The extra accounts enable employees to perform additional task functions for the enterprise. However, if an employee with multiple accounts for a given service leaves the organization, they can potentially use the accounts as access points for unauthorized entry into network systems.

Organizations should audit network systems where possible and delete extraneous accounts.

5. Consider password management tools. The majority of web browsers do offer basic password managers these days. But, they don’t offer as much value as dedicated password managers.

Password managers generate extremely strong passwords. Some password managers also offer passwordless authentication support, meaning that people can login with a one-time code, biometric authentication, a security key or Passkeys.

While there isn’t a 100% secure password management solution, password managers can serve as a useful support mechanism within a broader cyber security framework.

6. Ensure that two-step authentication has been implemented. Also known as multi-factor authentication, two step-authentication adds complexity to the login process, making it more difficult for a cyber criminal to gain illicit account access.

Two-step authentication enhances the overall resilience of digital identities and also helps to foster a culture of cyber security, as two-step auth means that users must actively participate in fortifying their online presence.

These days, two-step authentication is considered an essential element of a robust password security strategy.

7. Advanced anomaly detection systems. These types of systems can identify irregular patterns in login behavior. These include unusual access times, duplicative access, and logins from unfamiliar locations.

Admins can set up corresponding alerts and notifications. Personnel should regularly review and analyze logs generated by systems and are encouraged to take proactive measures in order to address any apparent risks.

Further information

If you’re wondering about the security of your accounts, or those within your organization, Google’s Password Checkup can show you which Google email addresses and passwords have been compromised in a breach. Another site that can be used to reliably detect compromised email addresses and passwords is Have I Been Pwned.

Related resources

  • 20 password management best practices – Info here
  • Gigya founder discusses passwordless authentication and new startup – See interview
  • Explore identity and access management resources and tools – Learn more