Here Are The Nominees For The 20th Annual BAFTA Games Awards

Here Are The Nominees For The 20th Annual BAFTA Games Awards

The 20th BAFTA Games Awards take place on Thursday, April 11. Streaming live on BAFTA’s’ YouTube and Twitch channels from Queen Elizabeth’s Hall in London starting at 7 p.m. BST/11 a.m. PT/2 p.m. ET, this spin-off of the prestigious film/TV awards show celebrates 40 games released in 2023 boasting “an outstanding level of creative excellence.” 

The full list of categories and nominees has been revealed. Baldur’s Gate 3 leads the pack with 10 nominations, though Marvel’s Spider-Man 2 and Alan Wake 2 aren’t far behind with 9 and 8 nominations, respectively. Winners are decided by BAFTA’s global membership comprised of experienced minds in the game industry. The EE Players’ Choice award is the only category open to public voting, which you can do here. The nominees are: 

Best Game

  • Alan Wake 2
  • Baldur’s Gate 3
  • Dave the Diver
  • The Legend of Zelda: Tears of the Kingdom
  • Marvel’s Spider-Man 2
  • Super Mario Bros. Wonder

Animation 

  • Alan Wake 2
  • Hi-Fi Rush
  • Hogwarts Legacy
  • Marvel’s Spider-Man 2
  • Star Wars Jedi: Survivor
  • Super Mario Bros. Wonder

Artistic Achievement 

  • Alan Wake 2
  • Baldur’s Gate 3
  • Cocoon
  • Diablo IV
  • Final Fantasy XVI
  • Hi-Fi Rush

Audio Achievement

  • Alan Wake 2
  • Call of Duty: Modern Warfare III
  • Hi-Fi Rush
  • The Legend of Zelda: Tears of the Kingdom
  • Marvel’s Spider-Man 2
  • Star Wars Jedi: Survivor

British Game

  • Cassette Beasts
  • Dead Island 2
  • Disney Illusion Island
  • Football Manager 2024
  • Viewfinder
  • Warhammer Age of Sigmar: Realms of Ruin

Debut Game

  • Cocoon
  • Dave the Diver
  • Dredge
  • Stray Gods: The Role-Playing Musical
  • Venba
  • Viewfinder

Evolving Game

  • Cyberpunk 2077
  • Final Fantasy XIV
  • Fortnite
  • Forza Horizon 5
  • Genshin Impact
  • No Man’s Sky

Family

  • Cocoon
  • Dave the Diver
  • Disney Illusion Island
  • Hi-Fi Rush
  • Hogwarts Legacy
  • Super Mario Bros. Wonder

Game Beyond Entertainment

  • Chants of Sennaar
  • Goodbye Volcano High
  • Tchia
  • Terra Nil
  • Thirsty Suitors

Game Design

  • Cocoon
  • Dave the Diver
  • Dredge
  • The Legend of Zelda: Tears of the Kingdom
  • Marvel’s Spider-Man 2
  • Viewfinder

Multiplayer

  • Baldur’s Gate 3
  • Call of Duty: Modern Warfare III
  • Diablo IV
  • Forza Motorsport
  • Party Animals
  • Super Mario Bros. Wonder

Music

  • Alan Wake 2
  • Assassin’s Creed Mirage
  • Baldur’s Gate 3
  • The Legend of Zelda: Tears of the Kingdom
  • Marvel’s Spider-Man 2
  • Star Wars Jedi: Survivor

Narrative

  • Alan Wake 2
  • Baldur’s Gate 3
  • Dredge
  • Final Fantasy XVI
  • The Legend of Zelda: Tears of the Kingdom
  • Star Wars Jedi: Survivor

New Intellectual Property

  • Chants of Sennaar 
  • Dave the Diver
  • Dredge
  • Hi-Fi Rush
  • Jusant
  • Viewfinder

Performer in a Leading Role

  • Amelia Tyler as Narrator – Baldur’s Gate 3
  • Cameron Monaghan as Cal Kestis – Star Wars Jedi: Survivor
  • Nadji Jeter as Miles Morales – Marvel’s Spider-Man 2
  • Neil Newbon as Astarion – Baldur’s Gate 3
  • Samantha Béart as Karlach – Baldur’s Gate 3
  • Yuri Lowenthal as Peter Parker – Marvel’s Spider-Man 2

Performer in a Supporting Role

  • Andrew Wincott as Raphael – Baldur’s Gate 3
  • Debra Wilson as Cere Junda – Star Wars Jedi: Survivor
  • Ralph Ineson as Cidolfus “Cid” Telamon – Final Fantasy XVI
  • Sam Lake as Alex Casey – Alan Wake 2
  • Tony Todd as Venom – Marvel’s Spider-Man 2
  • Tracy Wiles as Jaheira – Baldur’s Gate 3

Technical Achievement 

  • Alan Wake 2
  • Final Fantasy XVI
  • Horizon Call of the Mountain
  • The Legend of Zelda: Tears of the Kingdom
  • Marvel’s Spider-Man 2
  • Starfield

EE Player’s Choice

  • Baldur’s Gate 3
  • Cyberpunk 2077
  • Fortnite
  • The Legend of Zelda: Tears of the Kingdom
  • Lethal Company
  • Marvel’s Spider-Man 2

No Rest For The Wicked Cover Story, WWE 2K24, And The Impending Moomin Invasion | GI Show (Feat. Suriel Vazquez)

No Rest For The Wicked Cover Story, WWE 2K24, And The Impending Moomin Invasion | GI Show (Feat. Suriel Vazquez)

This week on The Game Informer Show podcast, host Marcus Stewart is joined by Kyle Hilliard, Charles Harte, and former Game Informer editor/current narrative designer at Big Blue Sky Games, Suriel Vazquez to talk about a smattering of video games, new and old. First up, we dive deep into our most recent cover story for No Rest for the Wicked, talk a bit about how realistic and nauseating the driving is in Pacific Drive, learn about WWE 2K24, and prepare for the impending Moomin invasion. We also mop up on some games like Like a Dragon: Infinite Wealth and Penny’s Big Breakaway before Suriel shares details about the game he has been working on, Merchants of Rosewall. And we finish out the show by answering some reader questions.

Watch The Video Version:

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Follow us on social media: Marcus Stewart (@MarcusStewart7), Kyle Hilliard (@KyleMHilliard), Charles Harte (@chuckduck365), Suriel Vazquez (@SurielVazquez)

The Game Informer Show is a weekly gaming podcast covering the latest video game news, industry topics, exclusive reveals, and reviews. Join host Alex Van Aken every Thursday to chat about your favorite games – past and present – with Game Informer staff, developers, and special guests from around the industry. Listen on Apple PodcastsSpotify, or your favorite podcast app.

The Game Informer Show – Podcast Timestamps:

00:00:00 – Intro
00:03:20 – Cover Story: No Rest for the Wicked
00:28:38 – Pacific Drive
00:40:03 – Snufkin: Melody of Moominvalley
00:48:20 – WWE 2K24 Review
01:02:06 – Like a Dragon: Infinite Wealth
01:12:17 – Penny’s Big Breakaway
01:16:11 – The Outlast Trials
01:22:51 – Housekeeping and Listener Questions
01:44:52 – The Lunch Break: Like A Dance Break but with Lunch (Working Title)

Vote For The Greatest Game Of All Time In Our Bracket Tournament

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No matter the industry – sports, television, movies, or games – the debate of “the greatest of all time” inevitably comes up. These debates are often full of superfluous apples-to-oranges comparisons and, as a result, are unlikely to come up with a definitive answer everyone will be happy with. But that’s what makes them so fun. In that spirit, we’re taking the month of March to hold our own bracket-style tournament, voted on by readers, to determine the greatest video game of all time.

Though we here at Game Informer assembled the bracket, even that was heavily influenced by our Reader Vote we held in 2018 to coincide with our 300th issue. Using the results of our 2018 Reader Vote combined with some input from staff, general sentiment in various online communities, and critical reception for more recent games, we assembled a starting bracket of 64 games. From here, we’ll hold two rounds of voting per week until we whittle this field down to one ultimate winner.

Will this result in a definitive selection of the best game ever released? Or will it reveal a coordinated effort from a particular gaming community committed to seeing their favorite game rise through the ranks? Only time will tell. 

While this is meant to be a fun experiment to see how the results shake out within the Game Informer readership and community, we hope you’ll come back to root for your favorites every Monday and Thursday until we are able to crown our champion in the 2024 Game Gauntlet. Be sure to bookmark this page or follow us on social media to be alerted when a new round starts! 

Vote For The Greatest Game Of All Time In Our Bracket Tournament

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Three MIT alumni graduate from NASA astronaut training

“It’s been a wild ride,” says Christopher Williams PhD ’12, moments after he received his astronaut pin, signifying graduation into the NASA astronaut corps.

Williams, along with Marcos Berríos ’06 and Christina “Chris” Birch PhD ’15, were among the 12-member class of astronaut candidates to graduate from basic training at NASA’s Johnson Space Center in Houston, Texas, on Tuesday, March 5.

NASA Astronaut Group 23 are the newest generation of Artemis astronauts, which includes 10 hailing from the United States, as well as two from the United Arab Emirates who trained alongside them.

During their more than two years of basic training, the group became proficient in such areas as spacewalking, robotics, space station systems, T-38 jets, and Russian language. The graduates also said that they asked endless questions about the functions of their spacesuit, which they wore while submerged in huge pools to practice spacewalks. They jumped into a frigid lake during a 10-day hike in Wyoming and shared the hauling of a 30-pound lava rock back to camp for more geology study, as well as the last bag of peanut M&Ms after running out of ready-to-eat meals during survival training in the Alabama back country.

“We feel ready to put our efforts and our energy into supporting NASA’s science on the space station or in support of our return to the moon and this program,” says Birch. “All of the Flies feel a great sense of responsibility and excitement for what comes next.”

The team earned the nickname “The Flies” from the previous astronaut class, the “Turtles,” and even designed their team patch into a housefly shape. (The team prefers calling themselves the Swarm, “which has a little bit more pizzazz,” says Birch.) “Traditionally, these names are usually things that do not take well to flight,” she adds. “We were really surprised that they gave us a flying creature. I think they have a lot of faith in us and hope that we fly soon.”

The Turtles were the first class to graduate under NASA’s Artemis program, in 2020. They included three aeronautics and astronautics alumni: Raja Chari SM ’01, Jasmin Moghbeli ’05, and Warren “Woody” Hoburg ’08. Former Whitehead Institute for Biomedical Research research fellow Kate Rubins, who was selected as a NASA astronaut in 2009 and had served as a flight engineer aboard the International Space Station, also joined the team.

After the newest graduates received their silver NASA astronaut pins, they joined the other 36 current astronauts eligible “to sit on the pointy end of a rocket” for such initiatives as assignments to the International Space Station, future commercial destinations, deep-space missions to destinations including the moon on NASA’s Orion spacecraft and Space Launch System rocket, and eventually, missions to Mars. The Artemis initiative also includes plans for the first woman and first person of color to walk on the moon.

For now, the Flies will be supporting all of these initiatives while Earthbound.

“Hopefully within next two or three years, my name will be called to go to space,” says Berrios. For now, he will stay in Houston, where he’ll be working in the human landing system program, including with private companies such as SpaceX and Blue Origin. He’ll also continue his training in advanced robotics and Russian, and he is training at various international partner countries working with space station modules.

Marcos Berrios

When he was selected to join the NASA astronaut program, Berríos had been serving as the commander of Detachment 1, 413th Flight Test Squadron and deputy director of the Combat Search and Rescue (CSAR) Combined Task Force. As a test pilot, he has accumulated more than 110 combat missions and 1,400 hours of flight time in more than 21 different aircraft.

Berríos calls Guaynabo, Puerto Rico, his hometown, and says he appreciated other Latino American astronauts, including Franklin R. Chang Diaz PhD ’77, serving as his role models and mentors. He hopes to do the same for others.

“Today hopefully marks another opportunity to open doors for others like me in the future, to recognize that the talent in the Latin American community is strong,” he said on the day of his graduation. His advice to those dreaming of being an astronaut is “to not give up, to stay curious, stay humble, be disciplined, and throughout all adversity, throughout all obstacles, that would all be worth it in the end.”

“I’ve always wanted to be an astronaut,” he says. He read a lot of astronaut autobiographies, and frequently Googled class 2.007 (Design and Manufacturing I), which led him to study mechanical engineering at MIT. He earned his master’s degree in mechanical engineering as well as a doctorate in aeronautics and astronautics from Stanford University, and then enrolled at the U.S. Naval Test Pilot School in Patuxent River, Maryland.

As a developmental test pilot at the CSAR Combined Test Force at Nellis Air Force Base in Nevada, he learned avionics, defensive systems, synthetic vision technologies, and electric vertical-takeoff-and-landing vehicles.

Berríos says that MIT, particularly while working with Professor Alexander Slocum, instilled within him the discipline required for his successes. “I don’t want to admit how spending, like, 24 hours on problem set after problem set just provided that attitude and mentality of like, ‘Yeah, this is tough, this is hard,’ but you know we’ve got the skills, we’ve got the resources, we’ve got our colleagues, and we’re going to figure it out … and we’re going to find a pretty novel way to solve it.”

He says he found spacewalk training to be especially tough “physically, because you’re in a pressurized spacesuit — it’s stiff, it requires strength and stamina — but also mentally, because you have to be focused for six hours at a time and maintain high awareness of your surroundings as well as for your partner.”

The new astronaut says he identifies first as an engineer and researcher. “We’re kind of a jack-of-all-trades,” he says. “One of the one of the amazing things about being an astronaut, and certainly one of the things that was very captivating for me about this job, was all of the different subject matters that we get to touch on. I mean, it’s incredible.”

Christina Birch  

An Arizona native, Birch graduated from the University of Arizona with bachelor’s degrees in mathematics, biochemistry, and molecular biophysics. As a doctoral candidate in biological engineering at MIT, she conducted original research at the intersection of synthetic biology, microfluidics, and infectious disease, and worked in the Jacquin Niles lab in the Department of Biological Engineering. “I really am grateful for (her advisor, Niles) taking me on, especially when he was starting up his lab.”

After graduation, she taught bioengineering at the University of California at Riverside, and scientific writing and communication at Caltech. But she didn’t forget the skills she gained while on the MIT cycling team; in 2018, she left academia to become a decorated track cyclist on the U.S. National Team. She was training for the 2020 Summer Olympics, while also working as a scientific consultant for startups in various technology sectors from robotics to vaccine development, when she was selected by NASA.

“I really need to give a shout out to the MIT cycling team,” she says. “They helped give me my start,” she says. “It was just a fantastic place to get a taste of that cycling community which I’m still a part of. I do still ride; I’m focused on longer-distance races, and I like to do gravel races.”

She’s also excited that the International Space Station has a bike trainer called CEVIS, and Teal CEVIS, to reduce muscle and bone loss experienced in microgravity.  

Her next role is to support the Orion program.

“Last week, I was out in San Diego supporting the underway recovery training, which is the landing and recovery team’s practice to recover crew from the Orion capsule after a simulated splashdown in the Pacific. It was just such an incredible learning opportunity for me getting up to speed on this this new vehicle. We’re doing the Orion 2 mission, which is really an incredible test flight.”

“The more I learn about the program, the more I see how many different elements that we are building from scratch,” she says. “What really sets NASA apart is our dedication to safety, and I know that we will fly astronauts to the moon when we’re ready, and now that comes under a little bit of my purview and my responsibilities.”

How does she incorporate her backgrounds in cycling and her biological engineering research into the space program? “The common link between my pursuit of the pointy edge of the bike race, and also original research at MIT, has always been the stepping into the unknown, comfort-pushing boundaries. Whether it’s getting into the T38 jet for the first time — I don’t have any prior aviation experience — and standing up in front of an audience to give a scientific lecture or to make an attack on the bike, you know I’ve done that emotional practice.

“I think being comfortable in discomfort and the unknown, stepping through that process with a rigorous sort of like engineering-questioning, is because MIT set me up so well with a strong foundation of understanding engineering principles, and applying those to big questions. Places where we don’t have full understanding of a system or how something works, and then there is spaceflight, how we are very much developing these technologies and testing them as we go. Ultimately, human lives are going to depend on asking really good questions.”

She says her biggest challenge so far has been diversifying her skill set.

“I had to make a pretty big transition when I arrived (to NASA training) because I had previously been in a mentality of trying to be the best in the world at something, be it the best in the world on the bike, or you know, being the expert in RNA aptamer malaria-targeting technologies, which is the research I was doing at MIT, and then having to switch to being both knowledgeable and skillful in a huge number of different areas that are required of an astronaut. I don’t have an aviation background so that was something very new, very exciting, and very fun, it turns out. But also having to develop spacewalk skills, learning to speak Russian, learning to fly a robotic arm, and learning all about the International Space Station systems, so going from a specialist, really, to a generalist was a pretty big transition.

“One of the hardest things about astronaut training is finding balance, because we are switching between all of these different technical topics, sometimes in the span of a day. You might be in the jet in the morning and then you have to turn around and go to an emergency simulation for a space station in the afternoon. Reid Wiseman, the commander of the Artemis 2 mission, says, ‘Be where your feet are.’ And that was some of the best advice that he gave us coming into the office as candidates.”

Christopher Williams

Williams knew going into the training program that he would learn things in which he had no prior background.

“When you’re flying in one of the T38 jets you’re having to do, you know, back-of-the-envelope math estimating things while operating in a dynamic environment,” he recalls. “Other things, like doing an underwater run in the spacesuit, to finding alternatives when conjugating Russian verbs … learning how to approach problems and to solve them came from my time at MIT. Going through the physics grad program there made me much stronger at taking new topics and just sort of digesting them, figuring out how to how to break them down and solve them.”   

He did end up working with many MIT alumni. “Lots of MIT people have rotated through, so I’ve had lots of good conversations with Kate Rubins and a bunch of folks that passed through AeroAstro [the Department of Aeronautics and Astronautics].”

Williams grew up in Potomac, Maryland, dreaming of being an astronaut. A private pilot and Eagle Scout, Williams spent much of his high school and Stanford University years at the U.S. Naval Research Laboratory in Washington, studying supernovae using the Very Large Array radio telescope, and researching supernovae at NASA’s Goddard Space Flight Center.   

At MIT, he pursued his doctorate in physics with a focus on astrophysics. When he wasn’t working as a campus emergency medical technician and volunteer firefighter, Williams and his advisor, Jackie Hewitt, built the Murchison Widefield Array, a low-frequency radio telescope array in Western Australia designed to study the epoch of reionization of the early universe. 

After graduation, he joined the faculty at Harvard Medical School, and was a medical physicist in the Radiation Oncology Department at the Brigham and Women’s Hospital and Dana-Farber Cancer Institute. As the lead physicist for the institute’s MRI-guided adaptive radiation therapy program, Williams focused on developing image guidance techniques for cancer treatments.  

He will be supporting the ongoing missions until it’s his turn to head to space. In the meantime, he looks forward to using his background in medicine to research how the human body is affected by space radiation and being in orbit.

“It’s strange, because as a scientist you know you’re kind of in a different role. There are physics experiments on the space station, and tons of biology and chemistry experiments. It’s actually really fun because I get to stretch different parts of my brain that I haven’t had to before.”

“We’re really representing all of NASA, all of America all over the world,” he says. “That’s a huge responsibility on us. I really want to make everybody proud.”

Encouraging the next generation of astronauts

After the graduation ceremonies ended, NASA announced that it is accepting applications for new astronaut candidates through April 2. 

Berrios advises MIT students that no matter what their background is, they should apply if they want to be an astronaut. “Try and express in words how your education, how your career, and how your hobbies relate to human space exploration. Chris [Birch] and I have very different backgrounds and combinations of skill sets … I guarantee the next class is going to have an individual from MIT that has a background that we haven’t even thought of yet.”

Birch says that just interviewing for the Artemis program “absolutely changed my life. I knew that even if I didn’t become an astronaut, I had met, you know, a real incredible group of people that inspired me to push further to do more to find another way to serve and so I would really just encourage people to apply. A lot of people (who were accepted) applied more than once.”

Adds Williams, “If you meet the requirements, just do it. If that’s your dream, tell people about it — because people will be excited for you and want to help you to achieve.”

JetBrains TeamCity Supply Chain Bug; 1,700+ servers unpatched

JetBrains TeamCity Supply Chain Bug; 1,700+ servers unpatched

EXECUTIVE SUMMARY:

Security experts have warned that cyber criminals are exploiting a critical TeamCity vulnerability en masse. Hackers are creating hundreds of new user accounts on compromised servers. 

TeamCity as a target

First released in 2006, the popular commercial software known as TeamCity enables developers to create and test software in an automated fashion.

It offers feedback on code changes and reduces code integration problems. It also has native support for Jira, Visual Studio, Bugzilla (bug tracking), Maven (build automation), and more than a dozen other tools.

TeamCity has been used to build everything from websites to banking systems. According to parent company JetBrains, over 30,000 organizations rely on TeamCity. But the tool’s popularity has presented security challenges.

In late 2023, experts raised concerns about APT29‘s active exploitation of a similar vulnerability in the TeamCity product. The current vulnerability, well, keep reading…

Current vulnerability details

The new vulnerability is listed as CVE-2024-27198. It’s an authentication bypass vulnerability in the web component of TeamCity on-premises.

As noted previously, the vulnerability is being exploited on a large-scale, which involves the creation of numerous new users on unpatched instances of TeamCity that are exposed on the public web.

Risk to supply chain

JetBrains did address the issue with a fix on Monday. However, more than 1,700 organizations have yet to receive the software update.

The vulnerable hosts are primarily located in Germany, the United States and Russia, with a few in China, the Netherlands and France. Of these, researchers believe that cyber criminals have already compromised more than 1,440 instances.

“There are between 3 and 300 users created on compromised instances, usually the pattern is 8 alphanum characters,” said a spokesperson from LeakIX, a search engine for exposed device misconfiguations and vulnerabilities.

The compromise of production machines used to build and deploy software (as TeamCity provides) could lead to supply chain attacks, as they may contain sensitive information about the environments where code is deployed, published or stored. Hackers could potentially extract information, reconfigure details and/or deploy a significant malware-based threat.

March 5th 2024: On March 5th, experts recorded a sharp spike in attempts to exploit CVE-2024-27198. The majority of attempts came from systems in the United States; on the DigitalOcean hosting infrastructure.

Unauthorized access to a TeamCity server could grant an attacker complete control over all aspects of projects — builds, agents and artifacts. Consequently, it serves as a suitable means through which to position an attacker to execute a supply chain attack.

Urgent update

The severity score for CVE-2024-27198 is 9.8 out of 10. The bug affects all TeamCity releases up to 2023.11.4 of the on-premise version.

Due to the widespread vulnerability exploitation, administrators of on-premise TeamCity instances are advised to take immediate steps surrounding the installation of the newest updates.

This incident underscores the importance of addressing vulnerabilities in a timely manner. It also speaks to the need to implement proactive threat detection mechanisms.

For further information about the TeamCity vulnerability, click here. Lastly, subscribe to the CyberTalk.org newsletter for more timely info, interviews and cutting-edge analyses, delivered straight to your inbox each week.

How the brain coordinates speaking and breathing

How the brain coordinates speaking and breathing

MIT researchers have discovered a brain circuit that drives vocalization and ensures that you talk only when you breathe out, and stop talking when you breathe in.

The newly discovered circuit controls two actions that are required for vocalization: narrowing of the larynx and exhaling air from the lungs. The researchers also found that this vocalization circuit is under the command of a brainstem region that regulates the breathing rhythm, which ensures that breathing remains dominant over speech.

“When you need to breathe in, you have to stop vocalization. We found that the neurons that control vocalization receive direct inhibitory input from the breathing rhythm generator,” says Fan Wang, an MIT professor of brain and cognitive sciences, a member of MIT’s McGovern Institute for Brain Research, and the senior author of the study.

Jaehong Park, a Duke University graduate student who is currently a visiting student at MIT, is the lead author of the study, which appears today in Science. Other authors of the paper include MIT technical associates Seonmi Choi and Andrew Harrahill, former MIT research scientist Jun Takatoh, and Duke University researchers Shengli Zhao and Bao-Xia Han.

Vocalization control

Located in the larynx, the vocal cords are two muscular bands that can open and close. When they are mostly closed, or adducted, air exhaled from the lungs generates sound as it passes through the cords.

The MIT team set out to study how the brain controls this vocalization process, using a mouse model. Mice communicate with each other using sounds known as ultrasonic vocalizations (USVs), which they produce using the unique whistling mechanism of exhaling air through a small hole between nearly closed vocal cords.

“We wanted to understand what are the neurons that control the vocal cord adduction, and then how do those neurons interact with the breathing circuit?” Wang says.

To figure that out, the researchers used a technique that allows them to map the synaptic connections between neurons. They knew that vocal cord adduction is controlled by laryngeal motor neurons, so they began by tracing backward to find the neurons that innervate those motor neurons.

This revealed that one major source of input is a group of premotor neurons found in the hindbrain region called the retroambiguus nucleus (RAm). Previous studies have shown that this area is involved in vocalization, but it wasn’t known exactly which part of the RAm was required or how it enabled sound production.

The researchers found that these synaptic tracing-labeled RAm neurons were strongly activated during USVs. This observation prompted the team to use an activity-dependent method to target these vocalization-specific RAm neurons, termed as RAmVOC. They used chemogenetics and optogenetics to explore what would happen if they silenced or stimulated their activity. When the researchers blocked the RAmVOC neurons, the mice were no longer able to produce USVs or any other kind of vocalization. Their vocal cords did not close, and their abdominal muscles did not contract, as they normally do during exhalation for vocalization.

Conversely, when the RAmVOC neurons were activated, the vocal cords closed, the mice exhaled, and USVs were produced. However, if the stimulation lasted two seconds or longer, these USVs would be interrupted by inhalations, suggesting that the process is under control of the same part of the brain that regulates breathing.

“Breathing is a survival need,” Wang says. “Even though these neurons are sufficient to elicit vocalization, they are under the control of breathing, which can override our optogenetic stimulation.”

Rhythm generation

Additional synaptic mapping revealed that neurons in a part of the brainstem called the pre-Bötzinger complex, which acts as a rhythm generator for inhalation, provide direct inhibitory input to the RAmVOC neurons.

“The pre-Bötzinger complex generates inhalation rhythms automatically and continuously, and the inhibitory neurons in that region project to these vocalization premotor neurons and essentially can shut them down,” Wang says.

This ensures that breathing remains dominant over speech production, and that we have to pause to breathe while speaking.

The researchers believe that although human speech production is more complex than mouse vocalization, the circuit they identified in mice plays the conserved role in speech production and breathing in humans.

“Even though the exact mechanism and complexity of vocalization in mice and humans is really different, the fundamental vocalization process, called phonation, which requires vocal cord closure and the exhalation of air, is shared in both the human and the mouse,” Park says.

The researchers now hope to study how other functions such as coughing and swallowing food may be affected by the brain circuits that control breathing and vocalization.

The research was funded by the National Institutes of Health.

Unpacking the Elon Musk vs. OpenAI Lawsuit

In the rapidly evolving landscape of artificial intelligence, a legal drama has unfolded that captures the intersection of visionary ideals and corporate realities. Elon Musk, a figure synonymous with groundbreaking advancements in technology, has initiated a lawsuit against OpenAI, the AI research organization he co-founded. The…