There’s a reason why today AI is all you hear about. We’ve experienced more AI innovation in the last 18 months than ever before. AI has exited the lab overnight and turned into a viable business driver. One industry that stands to win big is B2B…
John Forstrom, Co-Founder & CEO of Zencore – Interview Series
Zencore is a premier Google Cloud consulting and engineering partner, empowering organizations to succeed through expert guidance, comprehensive services, and a relentless focus on risk reduction and client success. John Forstrom is Zencore’s C-Founder and CEO, he is focused on helping companies make the transformation to…
The AI Mind Unveiled: How Anthropic is Demystifying the Inner Workings of LLMs
In a world where AI seems to work like magic, Anthropic has made significant strides in deciphering the inner workings of Large Language Models (LLMs). By examining the ‘brain’ of their LLM, Claude Sonnet, they are uncovering how these models think. This article explores Anthropic’s innovative…
‘Like A Dragon: Yakuza’ Live-Action Series Hits Amazon Prime Video This October
Amazon has announced Like a Dragon: Yakuza, a live-action television series adaptation of Ryu Ga Gotoku Studios and Sega’s long-running Like a Dragon (formerly Yakuza) series. It will be a story centered on series mainstay Kazuma Kiryu and will follow his life in 1995 and 2005 across six episodes.
The first three episodes drop Oct. 25 and the last three episodes hit Amazon Prime Video on Nov. 1, and, according to Variety, the series will be subbed and dubbed in 30 languages.
The logline for the series describes it as a story set in two time periods – 1995 and 2005 – and follows the life, childhood friendships, and repercussions of the decisions of Kazuma Kiryu, a Yakuza warrior with a strong sense of justice, duty, and humanity. If you’re familiar with the series, given the time periods at play here, it sounds like Like a Dragon: Yakuza could be loosely adapting the storyline of Yakuza 1.
Take Masaharu (100 Yen Love) is directing the series alongside Takimoto Kengo (Kamen Rider), and stars Takeuchi Ryoma (various Kamen Rider movies and series) as Kazuma Kiryu. You can see him in the image below:
Variety reports Like a Dragon: Yakuza will “depict the lives of fierce yet passionate gangsters and people living in a huge entertainment district, Kamurochō, a fictional district modeled after the violent Shinjuku ward’s Kabukichō, that acts as the backdrop of the gameplay.” Amazon says the series “showcases modern Japan and the dramatic stories of these intense characters, such as the legendary Kazuma Kiryu, that games in the past have not been able to explore.”
Ryu Ga Gotoku Studios studio head and series executive producer Yokoyama Masayoshi told Variety the following:
“Since the day I first put pen to paper on the original Yakuza script, I’ve never once thought about revisitng any of my work on the series. It’s because I understand all too well the challenges and hardships that come with remaking a finished title. However, if I were ever sent to the past through some kind of cosmic joke, this is the experience I’d want to create. If I had to go through the wringer anyhow, I’d want to make the most engaging versions of Kamurochō and Kazuma Kiryu I could – and this show has it all.
“While the games let you experience their world through the subjective lens, this adaptation will be the ultimately objective way to enjoy the show. I have no doubt fans of the series will be drawn to how it brings the games to life and adds new surprises. Newcomers, I’m sure, will find themselves invested simply in the gritty realism of the show.”
Like a Dragon: Yakuza hits Amazonz Prime Video starting on Oct. 25 and will finish on Nov. 1 this year.
News of this series follows the release of Like a Dragon: Infinite Wealth, the eighth mainline installment in the video game series, back in January. You can read Game Informer’s Like a Dragon: Infinite Wealth review here. After that, read Game Informer’s exclusive interview with the leads behind the Like a Dragon series to learn about the future of Ryu Ga Gotoku studio while visiting its offices.
Are you excited about Like a Dragon: Yakuza? Let us know in the comments below!
Amazon will use computer vision to spot defects before dispatch
Amazon will harness computer vision and AI to ensure customers receive products in pristine condition and further its sustainability efforts. The initiative – dubbed “Project P.I.” (short for “private investigator”) – operates within Amazon fulfilment centres across North America, where it will scan millions of products…
Ultrasound offers a new way to perform deep brain stimulation
Deep brain stimulation, by implanted electrodes that deliver electrical pulses to the brain, is often used to treat Parkinson’s disease and other neurological disorders. However, the electrodes used for this treatment can eventually corrode and accumulate scar tissue, requiring them to be removed.
MIT researchers have now developed an alternative approach that uses ultrasound instead of electricity to perform deep brain stimulation, delivered by a fiber about the thickness of a human hair. In a study of mice, they showed that this stimulation can trigger neurons to release dopamine, in a part of the brain that is often targeted in patients with Parkinson’s disease.
“By using ultrasonography, we can create a new way of stimulating neurons to fire in the deep brain,” says Canan Dagdeviren, an associate professor in the MIT Media Lab and the senior author of the new study. “This device is thinner than a hair fiber, so there will be negligible tissue damage, and it is easy for us to navigate this device in the deep brain.”
In addition to offering a potentially safer way to deliver deep brain stimulation, this approach could also become a valuable tool for researchers seeking to learn more about how the brain works.
MIT graduate student Jason Hou and MIT postdoc Md Osman Goni Nayeem are the lead authors of the paper, along with collaborators from MIT’s McGovern Institute for Brain Research, Boston University, and Caltech. The study appears today in Nature Communications.
Deep in the brain
Dagdeviren’s lab has previously developed wearable ultrasound devices that can be used to deliver drugs through the skin or perform diagnostic imaging on various organs. However, ultrasound cannot penetrate deeply into the brain from a device attached to the head or skull.
“If we want to go into the deep brain, then it cannot be just wearable or attachable anymore. It has to be implantable,” Dagdeviren says. “We carefully customize the device so that it will be minimally invasive and avoid major blood vessels in the deep brain.”
Deep brain stimulation with electrical impulses is FDA-approved to treat symptoms of Parkinson’s disease. This approach uses millimeter-thick electrodes to activate dopamine-producing cells in a brain region called the substantia nigra. However, once implanted in the brain, the devices eventually begin to corrode, and scar tissue that builds up surrounding the implant can interfere with the electrical impulses.
The MIT team set out to see if they could overcome some of those drawbacks by replacing electrical stimulation with ultrasound. Most neurons have ion channels that are responsive to mechanical stimulation, such as the vibrations from sound waves, so ultrasound can be used to elicit activity in those cells. However, existing technologies for delivering ultrasound to the brain through the skull can’t reach deep into the brain with high precision because the skull itself can interfere with the ultrasound waves and cause off-target stimulation.
“To precisely modulate neurons, we must go deeper, leading us to design a new kind of ultrasound-based implant that produces localized ultrasound fields,” Nayeem says. To safely reach those deep brain regions, the researchers designed a hair-thin fiber made from a flexible polymer. The tip of the fiber contains a drum-like ultrasound transducer with a vibrating membrane. When this membrane, which encapsulates a thin piezoelectric film, is driven by a small electrical voltage, it generates ultrasonic waves that can be detected by nearby cells.
“It’s tissue-safe, there’s no exposed electrode surface, and it’s very low-power, which bodes well for translation to patient use,” Hou says.
In tests in mice, the researchers showed that this ultrasound device, which they call ImPULS (Implantable Piezoelectric Ultrasound Stimulator), can provoke activity in neurons of the hippocampus. Then, they implanted the fibers into the dopamine-producing substantia nigra and showed that they could stimulate neurons in the dorsal striatum to produce dopamine.
“Brain stimulation has been one of the most effective, yet least understood, methods used to restore health to the brain. ImPULS gives us the ability to stimulate brain cells with exquisite spatial-temporal resolution and in a manner that doesn’t produce the kind of damage or inflammation as other methods. Seeing its effectiveness in areas like the hippocampus opened an entirely new way for us to deliver precise stimulation to targeted circuits in the brain,” says Steve Ramirez, an assistant professor of psychological and brain sciences at Boston University, and a faculty member at B.U.’s Center for Systems Neuroscience, who is also an author of the study.
A customizable device
All of the components of the device are biocompatible, including the piezoelectric layer, which is made of a novel ceramic called potassium sodium niobate, or KNN. The current version of the implant is powered by an external power source, but the researchers envision that future versions could be powered a small implantable battery and electronics unit.
The researchers developed a microfabrication process that enables them to easily alter the length and thickness of the fiber, as well as the frequency of the sound waves produced by the piezoelectric transducer. This could allow the devices to be customized for different brain regions.
“We cannot say that the device will give the same effect on every region in the brain, but we can easily and very confidently say that the technology is scalable, and not only for mice. We can also make it bigger for eventual use in humans,” Dagdeviren says.
The researchers now plan to investigate how ultrasound stimulation might affect different regions of the brain, and if the devices can remain functional when implanted for year-long timescales. They are also interested in the possibility of incorporating a microfluidic channel, which could allow the device to deliver drugs as well as ultrasound.
In addition to holding promise as a potential therapeutic for Parkinson’s or other diseases, this type of ultrasound device could also be a valuable tool to help researchers learn more about the brain, the researchers say.
“Our goal to provide this as a research tool for the neuroscience community, because we believe that we don’t have enough effective tools to understand the brain,” Dagdeviren says. “As device engineers, we are trying to provide new tools so that we can learn more about different regions of the brain.”
The research was funded by the MIT Media Lab Consortium and the Brain and Behavior Foundation Research (BBRF) NARSAD Young Investigator Award.
NVIDIA Unveils Rubin Platform: The Next-Gen AI Chip
In yet another big announcement at the Computex Conference in Taipei, NVIDIA CEO Jensen Huang unveiled more of the company’s plans for the future of AI computing. The spotlight shone on the Rubin AI chip platform, set to launch in 2026, and the Blackwell Ultra chip,…
CSS Length Units
A comprehensive guide covering nine types of lengths that CSS uses to size elements in terms of dimensions, space, time, and even sound.
CSS Length Units originally published on CSS-Tricks, which is part of the DigitalOcean family. You should get the newsletter….
Thinking Outside of the Box to Drive AI Innovation
For many of us innovating in the AI space, we are working in uncharted territory. Given how quickly AI companies are developing new technologies, one might take for granted the dogged work behind the scenes. But in a field like XR, where the mission is to…