7 actionable security automation best practices – CyberTalk

EXECUTIVE SUMMARY:

Nearly 75% of CEOs are concerned about their organizations’ abilities to avert or mitigate a cyber incident. It’s widely known that organizations need to become more resilient and to prioritize continuous delivery capabilities.

In our constantly evolving threat landscape, one key way to build resilience is through cyber security automation. Survey data indicates that more than 40% of organizations see automation as a “major factor” contributing to the successful improvement of their cyber security posture.

Security automation can streamline time-consuming, manual cyber security tasks and offer efficient threat prevention, investigation and incident response mechanisms. Automation also empowers security staff to dedicate time to strategic, higher-level cyber security tasks that otherwise might be sidelined.

Security automation, it’s not that simple…

However, to gain the aforementioned automation advantages, organizations need to adhere to relevant, industry-led best practices. Doing so not only ensures that organizations can harness the full potential of automated cyber security solutions, but also enables staff members to work in a synchronous and symbiotic way with solutions.

These seven actionable security automation best practices below will help your organization integrate the strengths of automation with those of human intelligence; maximizing the opportunities to thrive within complex, high-pressure and precision-centric enterprise ecosystems.

7 actionable security automation best practices

To achieve stronger cyber security outcomes through automation, unpack these savvy practitioner best practices:

1. Optimize the synergy. Automation excels in executing routine tasks. However, humans are still needed to bring in unique insights, contextual understanding and strategic thinking.

It’s the synergy between automation and skilled staff that’s key in an effective, modernized cyber security strategy. Reallocate resources to evolve and rethink human roles and to ensure alignment across ecosystem elements.

2. Commit to team training. Prepare for the shift from manual to automated response by providing team members with comprehensive training that’s tailored to individual roles. Reinforce the technical aspects of new automated solutions and the implications.

Clarify precisely what a security automation solution can handle, and where human intervention is critical. Clear explanations around this can prevent misunderstandings and can ensure that your team knows when to step in.

3. Prioritize automation initiatives. Assess and decide on which security issues are most pressing; map out the priorities. When you have a well-defined set of priorities, develop use-cases and evaluate opportunities for security workflow automation.

In the process, engage relevant stakeholders. Although bringing in a wider working group may slow down efforts, an inclusive approach ensures that key perspectives are heard, resulting in broader consensus and buy-in. This can prevent future roadblocks and resistance to automation adoption.

4. Take a measured approach. When it comes to security automation, most organizations can’t automate everything at once. But this may work to a given organization’s advantage.

Moving forward with automation in high-impact areas provides opportunities to build internal support for it and to showcase the effectiveness of automation tools. The initial results can reaffirm stakeholder buy-in and foster the momentum necessary to further expand automated initiatives.

A measured approach can serve as a foundation for a successful and adaptable automation strategy – one that aligns with your organization’s specific needs and objectives.

5. Create playbooks. Ahead of beginning the workflow automation process, ensure that workflows are as strong and as solid as possible. This will help when optimizing processes.

Then, develop playbooks. These will serve as the foundation upon which your automation efforts will be built.

Playbooks will help set the stage for successful automation process development that’s predicated upon a solid foundation of well-documented and optimized workflows.

6. Plan higher-level projects. Automation presents opportunities for your security team to contribute to your organization at a higher-level. Strategically consider how analysts may be able to redirect efforts into previously overlooked or under-attended value-add areas.

For instance, analysts may be able to spend time uncovering the root causes of persistent types of threats, such as phishing. Proactive investigations of root causes can assist with addressing underlying vulnerabilities. These kinds of activities can significantly contribute to the elevation of an organization’s cyber security posture.

7. Consider security orchestration. Integrating security orchestration alongside security automation enables organizations to seamlessly coordinate complex security workflows across multi-cloud environments. This can improve operational efficiency, communication and collaboration, and can also yield reduced response times.

For more insights into cyber security automation, please see CyberTalk.org’s past coverage or click here. Lastly, to receive timely cyber security insights and cutting-edge analyses, please sign up for the cybertalk.org newsletter.

Exploring Man’s Duality In RoboCop: Rogue City And Jusant | GI Show

In this week’s episode of The Game Informer Show, the crew explores two extremes: RoboCop: Rogue City — which is somehow the best RoboCop game — and Jusant, the meditative rock-climbing adventure that’s developer Don’t Nod’s best work since the original Life Is Strange. Later in the show, Kyle pantomimes WarioWare: Move It’s energetic mechanics before Alex dives into his most recent session of The Finals, which is currently the number one wishlisted game on Steam.

Watch Our Weekly Gaming Podcast:

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Follow us on social media: Alex Van Aken (@itsVanAken), Marcus Stewart (@MarcusStewart7), Kyle Hilliard (@KyleMHilliard)

The Game Informer Show is a weekly gaming podcast covering the latest video game news, industry topics, exclusive reveals, and reviews. Join host Alex Van Aken every Thursday to chat about your favorite games – past and present – with Game Informer staff, developers, and special guests from around the industry. Listen on Apple PodcastsSpotify, or your favorite podcast app.

The Game Informer Show – Podcast Timestamps:

00:00:00 – Intro

00:03:51 – Jusant Review

00:22:23 – RoboCop: Rogue City Review

00:43:03 – WarioWare: Move It!

00:54:40 – The Finals

01:07:17 – Housekeeping and Listener Questions

Enhancing Gaming Security with AI and Blockchain Integration

Online gaming has evolved immensely, transitioning from simple entertainment to a digital universe bustling with activity and transactions. However, with this growth comes the heightened risk of fraud. Understanding and resolving gaming security problems is crucial for maintaining trust and integrity within this virtual ecosystem. Understanding…

UBC and Honda Unveil Revolutionary Soft Sensor for Sensitive Robotics

In a groundbreaking development that promises to reshape the landscape of robotics and prosthetics, researchers at the University of British Columbia (UBC), in collaboration with Honda, have pioneered a smart, stretchable, and remarkably sensitive soft sensor. This cutting-edge technology stands to unlock a myriad of applications,…

The latest industry expert AI predictions for 2024

EXECUTIVE SUMMARY:

In this highly informative and engaging interview, Check Point expert Sergey Shykevich spills the tea on the trends that he and his threat intelligence team are currently seeing. You’ll get insights into what’s happening with AI and malware, you’ll find out about how nation-state hackers could manipulate generative AI algorithms, and get a broader sense of what to keep an eye on as we move into 2024.

Plus, Sergey also tackles the intellectual brain-teaser that is whether or not AI can express creativity (and the implications for humans). Let’s dive right in:

To help our audience get to know you, would you like to share a bit about your background in threat intelligence?

I’ve been in threat intelligence for 15 years. I’ve spent 10 years in military intelligence (various positions, mostly related to cyber space intelligence) and I’ve been in the private sector for around 6 years.

These last two years have been at Check Point, where I serve as the Threat Intelligence Group Manager for Check Point Research.

Would you like to share a bit about the cyber trends that you’ve seen across this year, especially as they relate to AI?

Yes. We have seen several trends. I would say that there are 3-4 main trends.

  • One trend we see, which is kind of in-flux, is in relation to ransomware ecosystem development. The ecosystem and the threat actors are increasingly operating more like nation-state actors, as they’re becoming very sophisticated.

    To illustrate my point, they now use multi-operation system malware. What does that mean? It means that they not only focus on Windows, but that they’re increasingly focused on Linux.

    This matters because, for many organizations, critical servers are Linux servers. In many cases, the impact of disrupting these servers is much bigger than, say, disrupting the activity of 100 Windows laptops, for instance.

    So, that’s a huge part of what’s happening in terms of ransomware. In addition, we’ve also seen mega ransomware events this year, like the MOVEit hack and use of it for a large-scale supply chain attack.

  • Another trend that we’re seeing is the resurgence of USB infections. When it comes to USBs, many consider it an old technology. A lot of people are no longer using them. And, the infection of USBs goes back to 2012, or even 2010 – with Stuxnet in Iran or the well-known Conficker malware. But what we’re seeing here is an influx in USB infections, as propagated by nation-state actors, like China and Russia, and by everyday cyber criminals.

    Why do we think that we’re seeing a resurgence of USB-based threats? We think that the barriers for hackers in other areas – such as network security and email security – have become much higher. So hackers are trying different methods, like USB infections.

  • We’re also seeing a resurgence of DDoS attacks. Mostly from hacktivist sites. They’re trying to disrupt the functionality of websites.
  • And of course, our team sees all of the threats related to AI. The AI-related threats that we observe are mostly related to phishing, impersonation and deepfakes.

    We do see AI used in malware development, but in terms of AI and malware, we aren’t seeing extremely sophisticated threats or threats that are “better” or more sophisticated than what a good code developer could create.

    In contrast, in relation to phishing and deepfakes, AI allows for a level of sophistication that’s unprecedented. For example, AI allows cyber criminals who don’t know a particular spoken language to craft perfect phishing emails in that language, making the emails sound like they were written by native-speakers.

    I would say that AI will be able to take malware to a new level in the near future, but we’re not there yet.

How can AI be leveraged to counter some of the threats that we’re seeing and that we’ll see into the future?

On the phishing and impersonation side, I think AI is being used and will mostly be used to identify specific patterns or anomalies within email content, which is no easy job for these tools. Most of the phishing content that’s created by AI is pretty good, especially since the data is now pulled directly from the internet (ex. the latest version of ChatGPT). The AI-based solutions can much better identify suspicious attachments and links, and can prevent the attacks in the initial stages.

But of course, the best way to counter AI-based phishing threats, as they exist right now, is still to avoid clicking on links and attachments.

Most cyber criminals aim to get people to take further action – to fill out a form, or to engage in some other activity that helps them. I think that a big thing that AI can do is to identify where a specific phishing email leads to, or what is attached to the email.

Of course, there’s also the possibility of using AI and ML to see what emails a person receives, whether or not they look like phishing emails (based on the typical emails that a person receives on the day-to-day). That’s another possible use-case for AI, but I think that AI is more often used for what I mentioned before; phishing attack assessment.

Could our cyber crime-fighting AI be turned against us?

In theory, yes. I think that this is more of an issue for the big, well-known AI models like ChatGPT — there are a lot of theoretical concerns about how these companies protect their models (or fail to).

There are really two main concerns here. 1) Will unauthorized people have access to our search queries and what we submit? 2) Manipulation — a topic about which there is even more concern than the first. Someone could manipulate a model to provide very biased coverage of a political issue, making the answer or answers one-sided. There are very significant concerns in this regard.

And I think everyone who develops AI or generative AI models that will be widely used needs to protect them from hacking and the like.

We haven’t seen such examples and I don’t have proof that this is happening, but I would assume that big nation state actors, like Russia and China, are exploring methods for how to manipulate AI algorithms.

If I were on their side, I would investigate how to do this because with hacking and changing models, you could influence hundreds of millions of people.

We should definitely think more about how we protect generative AI, from data integrity to user privacy and the rest.

Do you think that AI brings us closer to understanding human intelligence? Can AI be creative?

It’s an interesting set of questions. ChatGPT and Bing now have a variety of different models that can be used. Some of these are defined as ‘strict’ models while others are defined as ‘creative’ models.

I am not sure that it really helps us understand human intelligence. I think that it may put before us more questions than answers. Because I think that, as I mentioned previously, 99.999% of people who are using AI engines don’t really understand how they work.

In short, AI raises more questions and concerns than it does provide understanding about human intelligence and human beings.

For more AI insights from Sergey Shykevich, click here. Lastly, to receive timely cyber security insights and cutting-edge analyses, please sign up for the cybertalk.org newsletter.

WarioWare: Move It! Review, Super Mario RPG Preview | All Things Nintendo

This week on All Things Nintendo, Brian delivers his review of WarioWare: Move It, the latest game in Nintendo and Intelligent Systems’ zany microgame compilation series. After that, Kyle gives his early impressions of Super Mario RPG. The show wraps with some more impressions, this time from Metal Gear Solid Master Collection Vol. 1.

If you’d like to follow Brian on social media, you can do so on his Instagram/Threads @BrianPShea or Twitter @BrianPShea. You can follow Kyle on Twitter: @KyleMHilliard and BlueSky: @KyleHilliard.

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The All Things Nintendo podcast is a weekly show where we celebrate, discuss, and break down all the latest games, news, and announcements from the industry’s most recognizable name. Each week, Brian is joined by different guests to talk about what’s happening in the world of Nintendo. Along the way, they’ll share personal stories, uncover hidden gems in the eShop, and even look back on the classics we all grew up with. A new episode hits every Friday!

Be sure to subscribe to All Things Nintendo on your favorite podcast platform. The show is available on Apple PodcastsSpotifyGoogle Podcasts, and YouTube.


00:00:00 – Introduction
00:01:34 – Pokémon Scarlet & Violet Expansion Release Date
00:05:53 – Sakurai Speculates on Future of Smash Bros.
00:10:57 – Mario Kart 8 Deluxe Final Wave of DLC
00:15:50 – Hideki Kamiya and Shinji Mikami Collaborating?
00:18:27 – New Retro Games Added to Switch Online
00:22:32 – Twitch Ending Switch Support
00:24:04 – Atari Acquires Digital Eclipse
00:30:09 – WarioWare: Move It! Review
00:47:26 – Super Mario RPG Preview
00:57:31 – Metal Gear Solid Master Collection Vol. 1 Impressions
01:09:13 – eShop Gem of the Week: Pronty


If you’d like to get in touch with the All Things Nintendo podcast, you can email AllThingsNintendo@GameInformer.com, messaging Brian on Instagram (@BrianPShea), or by joining the official Game Informer Discord server. You can do that by linking your Discord account to your Twitch account and subscribing to the Game Informer Twitch channel. From there, find the All Things Nintendo channel under “Community Spaces.”


For Game Informer’s other podcast, be sure to check out The Game Informer Show with hosts Alex Van Aken, Marcus Stewart, and Kyle Hilliard, which covers the weekly happenings of the video game industry!

How Human Bias Undermines AI-Enabled Solutions

Last September, world leaders like Elon Musk, Mark Zuckerberg, and Sam Altman, OpenAI’s CEO, gathered in Washington D.C. with the purpose of discussing, on the one hand, how the public and private sectors can work together to leverage this technology for the greater good, and on the other…

How to decarbonize the world, at scale

The world in recent years has largely been moving on from debates about the need to curb carbon emissions and focusing more on action — the development, implementation, and deployment of the technological, economic, and policy measures to spur the scale of reductions needed by mid-century. That was the message Robert Stoner, the interim director of the MIT Energy Initiative (MITEI), gave in his opening remarks at the 2023 MITEI Annual Research Conference.

Attendees at the two-day conference included faculty members, researchers, industry and financial leaders, government officials, and students, as well as more than 50 online participants from around the world.

“We are at an extraordinary inflection point. We have this narrow window in time to mitigate the worst effects of climate change by transforming our entire energy system and economy,” said Jonah Wagner, the chief strategist of the U.S. Department of Energy’s (DOE) Loan Programs Office, in one of the conference’s keynote speeches.

Yet the solutions exist, he said. “Most of the technologies that we need to deploy to stay close to the international target of 1.5 degrees Celsius warming are proven and ready to go,” he said. “We have over 80 percent of the technologies we will need through 2030, and at least half of the technologies we will need through 2050.”

For example, Wagner pointed to the newly commissioned advanced nuclear power plant near Augusta, Georgia — the first new nuclear reactor built in the United States in a generation, partly funded through DOE loans. “It will be the largest source of clean power in America,” he said. Though implementing all the needed technologies in the United States through mid-century will cost an estimated $10 trillion, or about $300 billion a year, most of that money will come from the private sector, he said.

As the United States faces what he describes as “a tsunami of distributed energy production,” one key example of the strategy that’s needed going forward, he said, is encouraging the development of virtual power plants (VPPs). The U.S. power grid is growing, he said, and will add 200 gigawatts of peak demand by 2030. But rather than building new, large power plants to satisfy that need, much of the increase can be accommodated by VPPs, he said — which are “aggregations of distributed energy resources like rooftop solar with batteries, like electric vehicles (EVs) and chargers, like smart appliances, commercial and industrial loads on the grid that can be used together to help balance supply and demand just like a traditional power plant.” For example, by shifting the time of demand for some applications where the timing is not critical, such as recharging EVs late at night instead of right after getting home from work when demand may be peaking, the need for extra peak power can be alleviated.

Such programs “offer a broad range of benefits,” including affordability, reliability and resilience, decarbonization, and emissions reductions. But implementing such systems on a wide scale requires some up-front help, he explained. Payment for consumers to enroll in programs that allow such time adjustments “is the majority of the cost” of establishing VPPs, he says, “and that means most of the money spent on VPPs goes back into the pockets of American consumers.” But to make that happen, there is a need for standardization of VPP operations “so that we are not recreating the wheel every single time we deploy a pilot or an effort with a utility.”

The conference’s other keynote speaker, Anne White, the vice provost and associate vice president for research administration at MIT, cited devastating recent floods, wildfires, and many other extreme weather-related crises around the world that have been exacerbated by climate change. “We saw in myriad ways that energy concerns and climate concerns are one and the same,” she said. “So, we must urgently develop and scale low-carbon and zero-carbon solutions to prevent future warming. And we must do this with a practical, systems-based approach that considers efficiency, affordability, equity, and sustainability for how the world will meet its energy needs.”

White added that at MIT, “we are mobilizing everything.” People at MIT feel a strong sense of responsibility for dealing with these global issues, she said, “and I think it’s because we believe we have tools that can really make a difference.”

Among the specific promising technologies that have sprung from MIT’s labs, she pointed out, is the rapid development of fusion technology that led to MIT spinoff company Commonwealth Fusion Systems, which aims to build a demonstration unit of a practical fusion power reactor by the decade’s end. That’s an outcome of decades of research, she emphasized — the kinds of early-stage risky work that only academic labs, with help from government grants, can carry out.

For example, she pointed to the more than 200 projects that MITEI has provided seed funds of $150,000 each for two years, totaling over $28 million to date. Such early support is “a key part of producing the kind of transformative innovation we know we all need.” In addition, MIT’s The Engine has also helped launch not only Commonwealth Fusion Systems, but also Form Energy, a company building a plant in West Virginia to manufacture advanced iron-air batteries for renewable energy storage, and many others.

Following that theme of supporting early innovation, the conference featured two panels that served to highlight the work of students and alumni and their energy-related startup companies. First, a startup showcase, moderated by Catarina Madeira, the director of MIT’s Startup Exchange, featured presentations about seven recent spinoff companies that are developing cutting-edge technologies that emerged from MIT research. These included:

  • Aeroshield, developing a new kind of highly-insulated window using a unique aerogel material;
  • Sublime, which is developing a low-emissions concrete;
  • Found Energy, developing a way to use recycled aluminum as a fuel;
  • Veir, developing superconducting power lines;
  • Emvolom, developing inexpensive green fuels from waste gases;
  • Boston Metal, developing low-emissions production processes for steel and other metals;
  • Transaera, with a new kind of efficient air conditioning; and
  • Carbon Recycling International, producing cheap hydrogen fuel and syngas.

Later in the conference, a “student slam competition” featured presentations by 11 students who described results of energy projects they had been working on this past summer. The projects were as diverse as analyzing opposition to wind farms in Maine, how best to allocate EV charging stations, optimizing bioenergy production, recycling the lithium from batteries, encouraging adoption of heat pumps, and conflict analysis about energy project siting. Attendees voted on the quality of the student presentations, and electrical engineering and computer science student Tori Hagenlocker was declared first-place winner for her talk on heat pump adoption.

Students were also featured in a first-time addition to the conference: a panel discussion among five current or recent students, giving their perspective on today’s energy issues and priorities, and how they are working toward trying to make a difference. Andres Alvarez, a recent graduate in nuclear engineering, described his work with a startup focused on identifying and supporting early-stage ideas that have potential. Graduate student Dyanna Jaye of urban studies and planning spoke about her work helping to launch a group called the Sunrise Movement to try to drive climate change as a top priority for the country, and her work helping to develop the Green New Deal.

Peter Scott, a graduate student in mechanical engineering who is studying green hydrogen production, spoke of the need for a “very drastic and rapid phaseout of current, existing fossil fuels” and a halt on developing new sources. Amar Dayal, an MBA candidate at the MIT Sloan School of Management, talked about the interplay between technology and policy, and the crucial role that legislation like the Inflation Reduction Act can have in enabling new energy technology to make the climb to commercialization. And Shreyaa Raghavan, a doctoral student in the Institute of Data, Systems, and Society, talked about the importance of multidisciplinary approaches to climate issues, including the important role of computer science. She added that MIT does well on this compared to other institutions, and “sustainability and decarbonization is a pillar in a lot of the different departments and programs that exist here.”

Some recent recipients of MITEI’s Seed Fund grants reported on their progress in a panel discussion moderated by MITEI Executive Director Martha Broad. Seed grant recipient Ariel Furst, a professor of chemical engineering, pointed out that access to electricity is very much concentrated in the global North and that, overall, one in 10 people worldwide lacks access to electricity and some 2.5 billion people “rely on dirty fuels to heat their homes and cook their food,” with impacts on both health and climate. The solution her project is developing involves using DNA molecules combined with catalysts to passively convert captured carbon dioxide into ethylene, a widely used chemical feedstock and fuel. Kerri Cahoy, a professor of aeronautics and astronautics, described her work on a system for monitoring methane emissions and power-line conditions by using satellite-based sensors. She and her team found that power lines often begin emitting detectable broadband radio frequencies long before they actually fail in a way that could spark fires.

Admir Masic, an associate professor of civil and environmental engineering, described work on mining the ocean for minerals such as magnesium hydroxide to be used for carbon capture. The process can turn carbon dioxide into solid material that is stable over geological times and potentially usable as a construction material. Kripa Varanasi, a professor of mechanical engineering, said that over the years MITEI seed funding helped some of his projects that “went on to become startup companies, and some of them are thriving.” He described ongoing work on a new kind of electrolyzer for green hydrogen production. He developed a system using bubble-attracting surfaces to increase the efficiency of bioreactors that generate hydrogen fuel.

A series of panel discussions over the two days covered a range of topics related to technologies and policies that could make a difference in combating climate change. On the technological side, one panel led by Randall Field, the executive director of MITEI’s Future Energy Systems Center, looked at large, hard-to-decarbonize industrial processes. Antoine Allanore, a professor of metallurgy, described progress in developing innovative processes for producing iron and steel, among the world’s most used commodities, in a way that drastically reduces greenhouse gas emissions. Greg Wilson of JERA Americas described the potential for ammonia produced from renewable sources to substitute for natural gas in power plants, greatly reducing emissions. Yet-Ming Chiang, a professor in materials science and engineering, described ways to decarbonize cement production using a novel low-temperature process. And Guiyan Zang, a research scientist at MITEI, spoke of efforts to reduce the carbon footprint of producing ethylene, a major industrial chemical, by using an electrochemical process.

Another panel, led by Jacopo Buongiorno, professor of nuclear science and engineering, explored the brightening future for expansion of nuclear power, including new, small, modular reactors that are finally emerging into commercial demonstration. “There is for the first time truly here in the U.S. in at least a decade-and-a-half, a lot of excitement, a lot of attention towards nuclear,” Buongiorno said. Nuclear power currently produces 45 to 50 percent of the nation’s carbon-free electricity, the panelists said, and with the first new nuclear power plant in decades now in operation, the stage is set for significant growth.

Carbon capture and sequestration was the subject of a panel led by David Babson, the executive director of MIT’s Climate Grand Challenges program. MIT professors Betar Gallant and Kripa Varanasi and industry representatives Elisabeth Birkeland from Equinor and Luc Huyse from Chevron Technology Ventures described significant progress in various approaches to recovering carbon dioxide from power plant emissions, from the air, and from the ocean, and converting it into fuels, construction materials, or other valuable commodities.

Some panel discussions also addressed the financial and policy side of the climate issue. A panel on geopolitical implications of the energy transition was moderated by MITEI Deputy Director of Policy Christopher Knittel, who said “energy has always been synonymous with geopolitics.” He said that as concerns shift from where to find the oil and gas to where is the cobalt and nickel and other elements that will be needed, “not only are we worried about where the deposits of natural resources are, but we’re going to be more and more worried about how governments are incentivizing the transition” to developing this new mix of natural resources. Panelist Suzanne Berger, an Institute professor, said “we’re now at a moment of unique openness and opportunity for creating a new American production system,” one that is much more efficient and less carbon-producing.

One panel dealt with the investor’s perspective on the possibilities and pitfalls of emerging energy technologies. Moderator Jacqueline Pless, an assistant professor in MIT Sloan, said “there’s a lot of momentum now in this space. It’s a really ripe time for investing,” but the risks are real. “Tons of investment is needed in some very big and uncertain technologies.”

The role that large, established companies can play in leading a transition to cleaner energy was addressed by another panel. Moderator J.J. Laukatis, MITEI’s director of member services, said that “the scale of this transformation is massive, and it will also be very different from anything we’ve seen in the past. We’re going to have to scale up complex new technologies and systems across the board, from hydrogen to EVs to the electrical grid, at rates we haven’t done before.” And doing so will require a concerted effort that includes industry as well as government and academia.

Teen uses calculus learned through MITx to better understand his cancer treatment

When Dustin Liang was diagnosed with T-cell acute lymphoblastic leukemia in June, the cancer consumed his life. But despite a monthlong hospital stay, aggressive chemotherapy treatments, and ongoing headaches, fatigue, loss of appetite, and nausea, the 17-year-old high school senior enrolled in MITx’s class 18.01.1x (Calculus 1A: Differentiation).

MITx, part of MIT Open Learning, offers hundreds of high-quality massive open online courses adapted from the MIT classroom for learners worldwide. The Calculus 1A: Differentiation course was designed and created by the Department of Mathematics and offered through the MITx program. Liang took the free course this summer in between treatment sessions and medical tests so that he could meet the four-year math requirement to graduate from a Massachusetts high school — an arrangement he made with his school. 

In class, Liang learned how to differentiate functions and how to make linear and quadratic approximations. He then applied this knowledge to estimate his blood cell counts. “I was in a hospital bed when I saw the doctor draw a graph of my neutrophils on a whiteboard, and I thought you could apply a quadratic approximation to it to estimate my blood cell counts at a certain time in the future,” Liang recalls. “I talked to the doctors about it, and they said it was a good idea but that they currently didn’t have the technology to do that.”

When doctors conduct blood tests on a patient, they look at multiple cell counts. Three of those are especially important for cancer patients: hemoglobin, which is the protein in red blood cells responsible for the delivery of oxygen to tissues; platelets, tiny blood cells that help the body form clots to stop bleeding; and neutrophils, a type of white blood cell that helps the body fight infections.

“Heavy chemo kills all of the cells, regardless of whether they’re good or bad,” says Thomas Liang MS ’97, who is Dustin Liang’s father. “We asked the doctor a few times about the nadir [the lowest value of the neutrophil count after drug administration], but the doctors couldn’t predict when Dustin would get to it. The anxiety was pretty high.”

While Liang was in the intensive care unit, his doctors ordered blood tests hourly to get a clearer picture of his blood cell counts. Being able to predict blood cell counts allows doctors to more accurately manage the next treatment procedure, and it allows patients and their caregivers to be more cautious and prepare for the next treatment.

Predicting neutrophil counts with math

After being hospitalized for weeks, Liang couldn’t wait to go home. He had his eyes locked on his absolute neutrophil count, which needed to reach 1,000 per microliter of blood in order for Liang to get discharged. 

In Calculus 1A, Liang was learning how to predict the near future value of a function using linear or quadratic approximation methods. After seeing a doctor’s chart of his neutrophils, Liang hypothesized that he could use quadratic approximation to predict his neutrophil count. 

“Given a series of points of the blood cell counts, a function can be modeled,” Liang explains. “So, predicting a future point not far away is mathematically feasible.”

Determined to test his idea, Liang called his mentor, Jiawen Sun, who works in a London security exchange firm as a trading analyst simulating and modeling stock market behavior. Sun helped Liang create a graph to estimate Liang’s neutrophil count at a certain time. When Liang compared the graph to his blood test results, he found that the math worked.

“I was able to predict the blood cell counts. It was a little off, but close enough,” Liang says. “There are some challenges in simulating the function of blood cells. However, the human blood cell counts turned out to be converging easier than the stock market to simulate.”

Now, Liang is working on a more accurate model for the neutrophil count based on input he received from doctors at Dana-Farber Cancer Institute. He hopes to use data from other cancer patients to test his model; however, much more work will be needed to determine if this kind of model can be used on other patients.

“If this works, it will alleviate some of the anxiety of cancer patients, and make their lives a little bit easier,” Liang says. “For doctors, they will be able to come up with more accurate procedures for treating cancer.”

Searching for better treatment options

Liang completed Calculus 1A: Differentiation in September, receiving a grade of 100 percent on his final exam. “My other chemo had started, and I was feeling pretty bad when my dad told me the grade,” he recalls. “I’m proud I managed to accomplish something while I was undergoing chemo.”

Liang, who continues to undergo chemotherapy treatment, enrolled in class 18.01.2x (Calculus 1B: Integration) through MITx this fall semester. He is also taking an English class at his high school. After graduating from high school next year, Liang wants to study pre-med and become a cancer researcher. 

“I was always pretty interested in the science field. Then I got cancer, and I got even more interested in it,” he says. “I want to research it, find ways to help people get rid of their cancer, and better patients’ treatment.”

For Thomas Liang, his son’s survival is the first priority. “I want him to be a successful survivor,” he says. “Dustin is a brilliant kid and a chess prodigy. He thinks fast. He’s very sensitive. He doesn’t talk a lot, but is very popular among his friends. He’s a kindhearted kid. I am proud of his aspirations to be a doctor.”